Identifying the Demographic, Clinical, and Endoscopic Findings of Gastroesophageal Reflux Disease in Patients With Helicobacter pylori Infection at King Abdulaziz University Hospital, Jeddah, Saudi Arabia.

Background:   (. ) infection and gastroesophageal reflux disease (GERD) are widely spread clinical terms. GERD refers to the backflow of gastric acid to the esophagus and upper gastrointestinal tract, causing irritation. .  is a gram-negative bacillus that adheres mainly to the gastric mucosa, causing peptic ulcers and gastritis. The nature of the relationship between GERD and .  is yet to be explored, and few studies have been conducted. In contrast, some studies suggest a protective role of .  against GERD. This study aimed to identify the demographic, clinical, and endoscopic findings of patients with GERD who underwent .  testing.

Methods:  A retrospective review of medical records at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, between 2015 and 2021 was conducted in June 2021. Our sample consisted of 255 individuals enrolled based on age and .  status. In univariate analysis, we used frequency tests for qualitative data and measure of central tendency (MCT) for quantitative data. In bivariate analysis, we used the t-test and Pearson's chi-square test.

Results: Of 255 GERD patients enrolled, 90 were positive and 165 were negative for . The majority were females (54 were positive and 93 were negative for ). Both groups mainly complained of abdominal pain. Endoscopically, gastritis was higher in the -positive group than in the -negative group.

Conclusion:  In conclusion, the majority of GERD patients were . -negative, females, Saudis, and non-smokers.