The emergence of microbial diseases has become a major concern for humans. In the recent past, we have noticed the emergence and re-emergence of several microbes that include coronaviruses (severe acute respiratory syndrome coronavirus {SARS-CoV}, Middle-East respiratory syndrome coronavirus {MERS-CoV}, SARS-CoV-2), and others like Zika virus, Nipah virus, Influenza virus, and Ebola virus. These microbes have been noted to spill over from animals into humans. Several such microbes which were previously restricted to wild animals are now becoming responsible for infections in humans and have spread across the borders and resulted in pandemics. It has been more than two years since the discovery of the novel SARS-CoV-2 virus responsible for the coronavirus disease 2019 (COVID-19), and we are still struggling to cope-up with it and live normal lives. Recently, the monkeypox virus, which was confined to West and Central African countries, and caused endemic infections in monkeys and humans was associated with human infections in non-endemic regions like the United States of America (USA) and more than 30 other countries. Therefore, in this editorial, we attempt to put the spotlight on the monkeypox virus that is currently threatening to cause another widespread pandemic.
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http://dx.doi.org/10.7759/cureus.26577 | DOI Listing |
Pathology
December 2024
Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Viral infections of the central nervous system (CNS) have been emerging and re-emerging worldwide, and the Australasia region has not been spared. Enterovirus A71 and enterovirus D68, both human enteroviruses, are likely to replace the soon-to-be eradicated poliovirus to cause global outbreaks associated with neurological disease. Although prevalent elsewhere, the newly emergent orthoflavivirus, Japanese encephalitis virus (genotype IV), caused human infections in Australia in 2021, and almost certainly will continue to do so because of spillovers from the natural animal host-vector life cycle endemic in the country.
View Article and Find Full Text PDFFree Radic Biol Med
January 2025
Korea Mouse Phenotyping Center, Seoul National University, Seoul 08826, Republic of Korea; Laboratory of Developmental Biology and Genomics, Research Institute for Veterinary Science, and BK21 PLUS Program for Creative Veterinary Science Research, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea; Interdisciplinary Program for Bioinformatics, Program for Cancer Biology and BIO-MAX/N-Bio Institute, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:
Int J Infect Dis
January 2025
Center for Data and Knowledge Integration for Health (CIDACS), Oswaldo Cruz Foundation, Salvador, Brazil; Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.
Background Congenital Zika Syndrome (CZS) has been linked to a wide spectrum of abnormalities. However, differences in hospitalization patterns between children with and without CZS have not yet been investigated. Methods We compared rates of hospital admissions for all and specific diseases, proportions of admission causes, and total length of hospital stay (LOS) between children with CZS and those without the syndrome.
View Article and Find Full Text PDFVirology
January 2025
College of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang, PR China. Electronic address:
Porcine reproductive and respiratory syndrome virus (PRRSV) is a viral infectious disease that can cause infection in pigs of different ages. The condition known as porcine reproductive and respiratory syndrome poses a serious risk to the world's pig business and results in significant financial losses. Fuzhengjiedu San (FZJDS) is a traditional Chinese medicine compound, the main components include:Radix Isatidis, Radix Astragali and Herba Epimedii.
View Article and Find Full Text PDFTissue Barriers
January 2025
Sepsis Translational Medicine Key Laboratory of Hunan Province, Department of Pathophysiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, PR China.
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the result of an exaggerated inflammatory response triggered by a variety of pulmonary and systemic insults. The lung tissues are comprised of a variety of cell types, including alveolar epithelial cells, pulmonary vascular endothelial cells, macrophages, neutrophils, and others. There is mounting evidence that these diverse cell populations within the lung interact to regulate lung inflammation in response to both direct and indirect stimuli.
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