AI Article Synopsis
- SARS-CoV-2 vaccines are critical in controlling the COVID-19 pandemic, using various technologies like mRNA and viral vectors to stimulate immune responses.
- Researchers tested a new SARS-CoV-2 vaccine using the vaccinia virus Tiantan strain as a vector, which successfully produced strong antibody and T-cell responses in mice.
- The vaccinated mice demonstrated effective neutralizing activity against multiple SARS-CoV-2 variants, highlighting the potential for this approach in developing future vaccines.
Article Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines provide essential tools for the control of the COVID-19 pandemic. A number of technologies have been employed to develop SARS-CoV-2 vaccines, including the inactivated SARS-CoV-2 particles, mRNA to express viral spike protein, recombinant spike proteins, and viral vectors. Here, we report the use of the vaccinia virus Tiantan strain as a vector to express the SARS-CoV-2 spike protein. When it was used to inoculate mice, robust SARS-CoV-2 spike protein-specific antibody response and T-cell response were detected. Sera from the vaccinated mice showed strong neutralizing activity against the ancestral Wuhan SARS-CoV-2, the variants of concern (VOCs) B.1.351, B.1.617.2, and the emerging B.1.1.529 (omicron). This finding supports the possibility of developing a new type of SARS-CoV-2 vaccine using the vaccinia virus vector.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353262 | PMC |
| http://dx.doi.org/10.3389/fimmu.2022.911164 | DOI Listing |
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