Examining the association between serum IgG of oral bacteria and metabolic syndrome.

Aim: This investigation explored the relationship between oral bacteria and metabolic syndrome (METS).

Materials And Methods: There were 4,882 subjects enrolled in this cross-sectional study from the NHANES III database. The severity of periodontitis was classified into mild, moderate and severe. We measured oral bacterial antibodies. We examined the relationship between serum immunoglobulin G (IgG) antibodies of oral bacteria and METS performing multivariate regression analysis. Mediation analysis of oral bacteria on the correlation between periodontitis and METS was also executed.

Results: After adjusting for covariates, the serum IgG antibodies of , and were associated with the presence of METS ( = 0.006, = 0.014 and = 0.018, respectively). Furthermore, serum IgG antibodies of and were positively associated with the presence of METS ( = 0.001, = 0.011, and = 0.002, respectively) and ≥4 features of METS ( = 0.019, = 0.025, and = 0.02, respectively). IgG mediated 11.2% of the relationship between periodontitis and METS.

Conclusion: Serological markers of oral pathogens were correlated with the presence and the number of METS features after multivariable adjustment. Oral bacteria acted as a mediator of the correlation between periodontitis and METS. Our study provided a biologically plausible explanation for the association between periodontitis and METS, which provides a comprehensive evaluation of periodontitis.