The main mechanism of virulence in is the acquisition of virulence plasmids (KpVPs), which include two dominant types, namely, KpVP-1 (carrying 1, 1, , and ) and KpVP-2 (carrying 2, 2, and ). Both are non-conjugative and associated with different hypervirulent clones. In contrast to KpVP-1 reported in K1, K2, and other serotypes of , KpVP-2 was only reported in K2 strains and rarely characterized. In this study, we identified a conjugative KpVP-2-type virulence plasmid from a clinical hypervirulent strain. This plasmid was generated by the integration of conjugative transfer genes into the KpVP-2-type plasmid Kp52.145 II and could be readily conjugated to strain EC600 and strains of various types which are clinically existing, mediating hypervirulence. Furthermore, this kind of conjugative KpVP-2-type virulence plasmid has been disseminated in clinical settings in Hong Kong and other regions of the world. The generation of conjugative virulence plasmid may promote its transmission and explain the evolution of this type of virulence plasmid.
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| http://dx.doi.org/10.3389/fmicb.2022.914884 | DOI Listing |
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