AI Article Synopsis
- DIHS is a serious and rare drug reaction, with antithyroid drugs occasionally implicated, but cases involving propylthiouracil (PTU) are particularly rare.
- A patient presented with severe symptoms, including fever, skin rash, and dysfunction of the liver and kidneys, leading to a diagnosis of PTU-induced DIHS after supportive treatments were initiated.
- This case highlights the importance of recognizing DIHS in patients taking antithyroid drugs and emphasizes the need for timely diagnosis and treatment, marking it as the second documented case worldwide and introducing HLA typing for this condition.
Article Abstract
Background: Drug-induced hypersensitivity syndrome (DIHS) is a rare, potentially life-threatening systemic drug reaction. Antithyroid drugs (ATDs) causing DIHS have seldom been reported before.
Case Presentation: We present a case of propylthiouracil (PTU)-induced DIHS, which included fever, skin rash, lymphadenopathy, hepatosplenomegaly, serious liver and kidney dysfunction, peripheral blood eosinophilia, and atypical lymphocytosis. Following supportive therapy, intravenous immunoglobulin (IVIG), and systemic corticosteroid, the patient experienced a resolution of fever and rash combined with progressive normalization of hematological index and organ function. These clinical features, and the skin lesion biopsy confirmed DIHS diagnosis.
Conclusions: To our knowledge, this is the second reported case of PTU-induced DIHS worldwide and the first human leukocyte antigen (HLA) typing of PTU-induced DIHS. Clinicians should cautiously distinguish hyperthyroidism etiology and identify the indication of ATDs. Timely recognition and formal DIHS treatment are required in patients with ATDs.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357314 | PMC |
| http://dx.doi.org/10.1186/s13223-022-00707-w | DOI Listing |
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