AI Article Synopsis
- * Researchers used a specific model with Sprague Dawley rats as kidney donors and Wistar rats as recipients, measuring IL-17 levels at various days post-surgery through specialized techniques.
- * Results showed that IL-17 levels significantly increased in transplant recipients experiencing acute rejection, and using the immunosuppressant cyclosporin A helped prevent this increase.
Article Abstract
Background: To investigate the changes and significance of interleukin-17 (IL-17) in acute rejection following rat kidney transplantation.
Methods: Using inbred Sprague Dawley rats as donors and Wistar rats as recipients, an acute rejection model of kidney transplantation was established to evaluate the effects of IL-17. Reverse transcription polymerase chain reaction and immunohistochemistry were used to detect IL-17.
Results: Compared with those in the normal control group, the rats in the allogeneic transplantation (ATX) group had different degrees of acute rejection 3, 5, and 7 days after operation, and the expression of IL-17 mRNA in the transplanted kidney was significantly increased (P < .05). In the ATX group, acute rejection was observed 7 days after operation, and the integrated optical density (IOD) value of IL-17 was significantly increased (P < .05). Compared with the normal control group, acute rejection occurred in varying degrees at 3, 5, and 7 days after operation in the ATX group, and the IOD value of IL-17 significantly increased (P < .05).
Conclusions: IL-17 expression is increased in acute rejection after renal transplantation in rats. Other surgical factors in addition to acute rejection had no effect on IL-17 expression in rat kidney transplants. The immunosuppressant cyclosporin A was used to prevent the expression of IL-17 in rats with acute rejection.
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| http://dx.doi.org/10.1016/j.transproceed.2022.05.019 | DOI Listing |
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