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| http://dx.doi.org/10.1111/jpc.16144 | DOI Listing |
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Intra-arterial cocktail therapy for patients with anterior circulation large vessel occlusion who achieved endovascular reperfusion.
Front Neurol
December 2024
Department of Neurology, General Hospital of Northern Theater Command, Shenyang, China.
Background: Clinically ineffective reperfusion (CIR) refers to the discrepancy between successful reperfusion and a favorable functional outcome in patients with large vessel occlusion (LVO) stroke after endovascular treatment (EVT). The Improving Neuroprotective Strategy for Ischemic Stroke with Sufficient Recanalization after Thrombectomy by Intra-arterial Cocktail Therapy (INSIST-CT) trial aimed to explore the safety, feasibility, and efficacy of intra-arterial cocktail therapy using argatroban, dexamethasone, and edaravone in patients who achieved sufficient reperfusion after EVT.
Methods: In this prospective, single-arm, pilot study, eligible patients with anterior circulation LVO who achieved sufficient reperfusion after EVT were enrolled in the INSIST-CT trial.
Outcomes of treatment cessation after switching to subcutaneous vedolizumab treatment in inflammatory bowel diseases.
Therap Adv Gastroenterol
October 2024
Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Kálvária Avenue 57, Szeged H-6725, Hungary.
Article Synopsis
- The study investigates the effectiveness, safety, and patient preferences associated with switching from intravenous to subcutaneous vedolizumab treatment for inflammatory bowel diseases over a 52-week period.
- A total of 70 patients were included, with high rates of clinical and biochemical remission observed in both ulcerative colitis and Crohn's disease groups, while 17.1% discontinued the treatment primarily due to loss of response.
- Overall, switching to subcutaneous administration showed effective treatment persistence, stable remission rates, and no new safety concerns.
Patient-specific 3D-printed Brace for Adolescent Idiopathic Scoliosis: A Prospective Cohort Study.
World Neurosurg
September 2024
Department of Orthopaedics, Peking University Third Hospital, Beijing, China; Beijing Key Laboratory of Spinal Disease Research, Peking University Third Hospital, Beijing, China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Peking University Third Hospital, Beijing, China.
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- The study aimed to assess the effectiveness and safety of personalized 3D printed braces for treating adolescent idiopathic scoliosis (AIS) and to compare their impact on patients' health-related quality of life (HRQoL) against traditional braces.
- Over a three-year period, 103 AIS patients were monitored, and their compliance with brace usage and the progression of spinal curvature were evaluated through clinical exams and standardized questionnaires.
- Results showed that the 3D printed brace (3DPB) had a lower maximum Cobb angle of curvature compared to the traditional thoracolumbosacral orthosis (TLSO), indicating better outcomes in terms of both curve progression and weight, suggesting 3DPB may be a more effective treatment option
Investigating pupillometry to detect preoperative anxiety: a pilot study.
Front Psychol
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Department of Anaesthesia and Intensive Care, Hopital Cochin, Assistance Publique-Hopitaux de Paris, Paris, France.
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- The European Society of Anesthesia emphasizes the need for managing preoperative anxiety, but current assessment methods using lengthy questionnaires can be impractical.
- A study involving 71 patients undergoing outpatient eye surgery evaluated preoperative anxiety with the Surgical Fear Questionnaire (SFQ) and measured pupillary responses using a pupillometer.
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Determination of biological activities of malabar spinach () fruit extracts and molecular docking against COX-II enzyme.
Heliyon
November 2023
Dept. of Genetic Engineering and Biotechnology, Jashore University of Science and Technology, Jashore-7408, Bangladesh.
To achieve the health benefit from the natural of fruit. This study intended to figure out the bioactive compounds in the two varieties of (native and hybrid) fruit extract and measurement its biological activities like antioxidant, anti-inflammatory, cytotoxic activities and a molecular docking were performed to observed the pharmaceutical impact on the anti-inflammatory Cyclooxygenase-2 (COX-2) enzyme. The cold extractions along with GC-MS were used for the extraction of and analysis of phytoconstituents from fruit.
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