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Giant cell interstitial pneumonia: case series with comprehensive ultrastructural analyses of "not only" hard metal pneumoconiosis.
Histopathology
February 2025
Surgical Pathology and Cytopathology Unit, University Hospital of Padova, Padova, Italy.
Article Synopsis
- - Giant cell interstitial pneumonia (GIP) is a serious lung disease related to exposure to hard metals like tungsten, typically found in industrial tools, but it can also occur without clear exposure history.
- - In a study of five patients with GIP, researchers used advanced techniques to identify metal dust and asbestos in lung samples, finding trace amounts of tungsten and asbestos fibers associated with severe lung damage.
- - The results suggest that other factors beyond hard metal exposure might contribute to GIP's development, hinting at a complex immune mechanism that could explain its recurrence in lung transplants.
3D printed polylactic acid/polyethylene glycol/bredigite nanocomposite scaffold enhances bone tissue regeneration via promoting osteogenesis and angiogenesis.
Int J Biol Macromol
November 2024
Materials Engineering Group, Golpayegan College of Engineering, Isfahan University of Technology, Golpayegan 87717-67498, Iran.
Recently, the fabrication of personalized scaffolds with high accuracy has been developed through 3D printing technology. In the current study, polylactic acid/polyethylene glycol (PLA/PEG) composite scaffolds with varied weight percentages (0, 5, 10, 20 and 30 %) of bredigite nanoparticles (B) were fabricated using the 3D printing and then characterized through scanning electron microscopy and Fourier transform infra-red spectroscopy. The addition of B nanoparticles up to 20 wt% to PLA/PEG scaffold increased the compressive strength (from 7.
View Article and Find Full Text PDFRecycling thermally deactivated asbestos cement in mortar: A possible route towards a rapid conclusion of the "asbestos problem".
J Environ Manage
March 2024
RALLK S.R.L., Via Pastrengo 21, Milano, Italy. Electronic address:
The "asbestos problem" arises from the fact that asbestos is still abundant in many buildings and represents a hazard for human health. Current strategies adopted by law aiming at mitigating this hazard are far from being ideal. A smarter solution would be an energy sustainable detoxification treatment followed by recycling.
View Article and Find Full Text PDFRapid fiber-detection technique by artificial intelligence in phase-contrast microscope images of simulated atmospheric samples.
Ann Work Expo Health
April 2024
National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan.
Since the manufacture, import, and use of asbestos products have been completely abolished in Japan, the main cause of asbestos emissions into the atmosphere is the demolition and removal of buildings built with asbestos-containing materials. To detect and correct asbestos emissions from inappropriate demolition and removal operations at an early stage, a rapid method to measure atmospheric asbestos fibers is required. The current rapid measurement method is a combination of short-term atmospheric sampling and phase-contrast microscopy counting.
View Article and Find Full Text PDFMesenchymal stromal cells loaded with Paclitaxel (PacliMES) a potential new therapeutic approach on mesothelioma.
Biochem Pharmacol
August 2023
CRC StaMeTec, Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy.
Malignant pleural mesothelioma is an asbestos-related tumor originating in mesothelial cells of the pleura that poorly responds to chemotherapeutic approaches. Adult mesenchymal stromal cells derived either from bone marrow or from adipose tissue may be considered a good model for cell-based therapy, a treatment which has experienced significant interest in recent years. The present study confirms that Paclitaxel is effective on mesothelioma cell proliferation in 2D and 3D in vitro cultures, and that 80,000 mesenchymal stromal cells loaded with Paclitaxel inhibit tumor growth at a higher extent than Paclitaxel alone.
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