Zhang et al. (2022) report that itaconate, a mitochondrial metabolite produced by macrophages upon inflammatory stimuli, activates the master regulator of lysosomal biogenesis TFEB to facilitate clearance of invading bacteria and efficient immune response.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.molcel.2022.06.009 | DOI Listing |
Publication Analysis
Top Keywords
irg1/itaconate/tfeb axis
4
axis weapon
4
weapon macrophage
4
macrophage antibacterial
4
antibacterial defense
4
defense zhang
4
zhang et al
4
et al 2022
4
2022 report
4
report itaconate
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!