Two new monoterpenoid indole alkaloids 3-hydroxylochnerine () and 10-hydroxyvinorine () were isolated from the roots of . Their structures were elucidated based on the analysis of spectroscopic data and ECD calculation. Both compounds exhibited potent antimicrobial activity against and , and their activities were comparable to the well-known antibacterial drug berberine.
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http://dx.doi.org/10.1080/10286020.2022.2104258 | DOI Listing |
Int J Mol Sci
November 2024
College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Inflammation assumes a vital role in the pathogenesis of depression and in antidepressant treatment. Paeoniflorin (PF), a monoterpene glycoside analog possessing anti-inflammatory attributes, exhibits therapeutic efficacy on depression-like behavior in mice. The objective of this study was to evaluate the antidepressant effects of PF on depression elicited by the chronic unpredictable mild stress (CUMS) model and the precise neural sequence associated with the inflammatory process.
View Article and Find Full Text PDFPhytochemistry
December 2024
School of Pharmaceutical Science & Yunnan Provincial Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, China; Yunnan College of Modern Biomedical Industry, Kunming Medical University, Kunming, 650500, China. Electronic address:
Voagafries A-E, five undescribed monoterpenoid indole alkaloids (MIAs), were isolated from the stem bark of Voacanga africana. Voagafrie A (1) has a unique 6/5/5/6/6 spiral ring skeleton with an indolone-fused 9-oxo-3-aza-tricyclo[6,3,1,0]-12-alkane-10-carbonyllactone. Voagafrie B (2) is a rare 5,6-seco diazine scaffold, whereas voagafrie C (3) possesses an octahydropyrrolo[2,3-b] pyrrole-fused 2,8-diazabicyclo[3.
View Article and Find Full Text PDFFitoterapia
December 2024
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address:
Alstoscholarisine L is an architecturally complex monoterpenoid indole alkaloid with a unique ring fusion pattern, isolated from the leaves of Alstonia scholaris. The 6/5/5/6/6/6-membered rings contain two lactonic rings and one aminal carbon and possess seven contiguous aligned stereocenters, three of which are quaternary. Its structure was elucidated by extensive spectroscopic data analyses, quantum chemical computations, and single-crystal X-ray diffraction.
View Article and Find Full Text PDFPlant Physiol Biochem
November 2024
Biomolécules et Biotechnologies Végétales, EA2106, Université de Tours, 37200, Tours, France. Electronic address:
Monoterpene indole alkaloids (MIAs) are valuable metabolites produced in numerous medicinal plants from the Apocynaceae family such as Alstonia scholaris, which synthesizes strictamine, a MIA displaying neuropharmacological properties of a potential importance. To get insights into the MIA metabolism in A. scholaris, we studied here both the spatial and transcriptional regulations of MIA genes by performing a robust transcriptomics analysis of the main plant organs, leaf epidermis but also by sequencing RNA from leaves transiently overexpressing the master transcriptional regulator MYC2.
View Article and Find Full Text PDFNat Prod Res
December 2024
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou, The People's Republic of China.
A phytochemical investigation on the stems and leaves of caused the isolation and characterisation of a new monoterpenoid indole alkaloid, damnahainanline (), as well as seven known analogues (-). The molecular structure of was determined in the light of comprehensive spectroscopic data analyses and the known analogues - were determined comparing their experimental spectroscopic data with the reported spectroscopic data in the literature. The anti-inflammatory effects as well as anti-HIV activities of all isolates - were assessed.
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