Herein, we report a three-component organophotoredox coupling of -alkenyl amides with α-bromocarbonyls and various nucleophiles. This transition metal-free difunctionalization protocol installs sequential C-C and C-Y (Y = S/O/N) bonds in alkenes. This reaction works with terminal and internal alkenes containing both cyclic and acyclic amides radical-polar crossover.
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| http://dx.doi.org/10.1039/d2cc04101d | DOI Listing |
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