7-Methoxy-13-dehydroxypaxilline: New indole diterpenoid from an endophytic fungus sp. Nb 19.

Nat Prod Res

Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Jinghong, China.

Published: December 2023

ABSTACTA chemical investigation of the endophyte sp. Nb 19, isolated from leaves of the traditionally medical plant (Nees) Bremek., yielded one new indole diterpenoid, 7-methoxy-13-dehydroxypaxilline () together with seven known metabolites (-). The obtained structure of compound was elucidated by its spectroscopic data. In addition, the absolute configuration of compound was confirmed by ECD for the first time. Compounds - were evaluated for antitumor activity against MCF-7, HepG2, and HCCC-9810 cell lines.

Download full-text PDF

Source
http://dx.doi.org/10.1080/14786419.2022.2107639DOI Listing

Publication Analysis

Top Keywords

indole diterpenoid
8
7-methoxy-13-dehydroxypaxilline indole
4
diterpenoid endophytic
4
endophytic fungus
4
fungus abstacta
4
abstacta chemical
4
chemical investigation
4
investigation endophyte
4
endophyte isolated
4
isolated leaves
4

Similar Publications

sp. nov., a bacterium isolated from the roots of the aquatic plant .

Int J Syst Evol Microbiol

January 2025

Department of Biology, Slippery Rock University, Slippery Rock, Pennsylvania 16057, USA.

A polyphasic taxonomic study was carried out on strain T9W2-O, isolated from the roots of the aquatic plant . This isolate is rod-shaped, forms yellow/orange pigmented colonies and produces the pigment flexirubin. Nearly complete 16S rRNA gene sequence homology related the strain to , with 98.

View Article and Find Full Text PDF

The lily is a globally popular cut flower, and managing dormancy in lily bulblets is essential for continuous, year-round production. While nitric oxide (NO) has been shown to influence seed dormancy and germination, its role in dormancy release in lilies was previously unconfirmed. In this study, we investigated the effects of NO on dormancy release in lily bulblets using SNP and c-PTIO.

View Article and Find Full Text PDF

Chemotherapy resistance in triple-negative breast cancer (TNBC) leads to poor therapeutic effects and a poor prognosis. Given that paclitaxel-based chemotherapy is the main treatment method for TNBC, enhancing its chemosensitivity has been a research focus. Induced ferroptosis of tumour cells has been proven to increase chemosensitivity, but its ability to sensitize TNBC cells to paclitaxel (PTX) is unknown.

View Article and Find Full Text PDF

In 1973, Jaffe identified and characterized the phenomenon of thigmomorphogenesis, also referred to as mechanical stress (MS) or mechanical stimulation in plants. Previous studies on petunia plants demonstrated that MS significantly affects growth dynamics. As a response to MS, petunias exhibit increased levels of indole-3-acetic acid (IAA) oxidase and peroxidase, although the active transport of endogenous IAA remains unaffected.

View Article and Find Full Text PDF

Paclitaxel is a widely used chemotherapeutic agent for the treatment of breast cancer (BC), including as a front-line treatment for triple-negative breast cancer (TNBC) patients. However, resistance to paclitaxel remains one of the major causes of death associated with treatment failure. Multiple studies have demonstrated that miRNAs play a role in paclitaxel resistance and are associated with both disease progression and metastasis.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!