Light-induced stabilization of microtubules by photo-crosslinking of a Tau-derived peptide.

Chem Commun (Camb)

Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan.

Published: August 2022

For light-induced stabilization of microtubules (MTs) to manipulate cells, a photo-reactive diazirine group was conjugated to a Tau-derived peptide, a motif binding on the inside of MTs. Ultraviolet (UV) light irradiation induced significant stabilization of MTs the formation of a covalent bond of the peptide and showed toxicity.

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http://dx.doi.org/10.1039/d2cc01890jDOI Listing

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