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Computational Analysis of Flow and Transport Suggests Reduced Oxygen Levels Within Intracranial Aneurysms, Especially in Individuals With Sickle-Cell Disease.
J Biomech Eng
February 2025
Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455.
Sickle cell disease (SCD) is a genetic condition characterized by an abundance of sickle hemoglobin in red blood cells. SCD patients are more prone to intracranial aneurysms (ICA) compared to the general population, with distinctive features such as multiple intracranial aneurysms: 66% of SCD patients with ICAs have multiples ICAs, compared to 20% in nonsickle patients. The exact mechanism behind these associations is not fully understood, but there is a hypothesized link between hypoxic conditions in blood vessels and impaired synthesis of extracellular matrix, which may weaken the vessel walls, favoring aneurysm formation and rupture.
View Article and Find Full Text PDFAvascular necrosis in sickle cell disease needs more definitive treatment options.
Br J Haematol
November 2024
Division of Hematology and Oncology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Avascular necrosis (AVN) is a bone disease caused by a temporary or definitive loss of the blood supply to bone resulting in cellular death. In people with sickle cell disease (SCD), AVN is one of the most common causes of severe chronic pain. Currently, there are very few treatment options for AVN and the current study by Casale et al.
View Article and Find Full Text PDF"You Can't Let Go" - A Black Community Leader's Perspective on Engagement and Advocacy.
Healthc Policy
September 2024
President/CEO Sickle Cell Awareness Group of Ontario, North York, ON.
Lanre Tunji-Ajayi is president and CEO of the Sickle Cell Awareness Group of Ontario (SCAGO). This charitable organization focuses on ameliorating the lives of those living with sickle cell disease by providing evidence-based support to patients and supporting clinical and psychosocial research, health promotion and the development of best practice guidelines. Lanre's passion for this work is personal.
View Article and Find Full Text PDFImproving the Lives of People with Sickle Cell Disease: Community Organizations and Epidemiologists Working Together.
Prog Community Health Partnersh
September 2024
Background: The Centers for Disease Control and Prevention's Sickle Cell Data Collection (SCDC) program comprises multidisciplinary teams, which include community-based organizations. Partnering with community-based organizations (CBOs) is a novel approach to ensure that SCDC data are actionable.
Objective: To better understand areas for mutual capacity building, we explored the relationships and dynamics between CBO and data teams within the SCDC program in 10 states.
Fostering a healthier generation of children with sickle cell disease through advancements in care.
Pediatr Res
September 2024
Alpert Medical School of Brown University, Providence, RI, USA.
Sickle cell disease (SCD) is an inherited disorder of hemoglobin that affects tens of millions of individuals worldwide. Without preventive and disease-modifying therapy, SCD results in many acute and chronic complications impacting both quality and length of life. We are currently in a new generation of SCD care in high resource settings due to recent advancements in care.
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