Prenatal screening for sex chromosome aneuploidies (SCAs) is increasingly available through expanded non-invasive prenatal testing (NIPT). NIPT for SCAs raises complex ethical issues for clinical providers, prospective parents and future children. This paper discusses the ethical issues that arise around NIPT for SCAs and current guidelines and protocols for management. The first section outlines current practice and the limitations of NIPT for SCAs. It then outlines key guidelines before discussing the ethical issues raised by this use of NIPT. We conclude that while screening for SCAs should be made available for people seeking to use NIPT, its implementation requires careful consideration of what, when and how information is provided to users.
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http://dx.doi.org/10.1002/pd.6217 | DOI Listing |
Seizure
January 2025
University of Adelaide, Adelaide SA 5005, Australia; Flinders University, Bedford Park SA 5042, Australia; Lyell McEwin Hospital, Elizabeth Vale SA 5112, Australia; Department of Neurology and the Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston MA 02138, USA.
Purpose: Epilepsia partialis continua (EPC) is form of focal motor status epilepticus, with limited guidelines regarding effective pharmacological management. This systematic review aimed to describe previously utilized pharmacological management strategies for EPC, with a focus on patient outcomes.
Methods: A systematic review of the databases PubMed, EMBASE, and SCOPUS was performed from inception to May 2024.
Acta Cir Bras
January 2025
Universidade Federal de Pernambuco - Pós-Graduação em Medicina Tropical - Recife (PB) - Brazil.
Purpose: To evaluate intravenous meropenem and intraperitoneal 10% aqueous extract of Schinus terebinthifolius (aroeira) in elderly rats after autogenous fecal peritonitis.
Methods: Thirty 18-month-old Wistar rats underwent peritonitis with 4 mL/kg of autogenous fecal solution. They were stratified into groups: control without treatment; study I, treated with meropenem (40 mg/kg); and study II, treated with meropenem at the same dose and intraperitoneal 10% aqueous extract of aroeira.
Rev Bras Enferm
January 2025
Universidade de São Paulo. São Paulo, São Paulo, Brazil.
Objective: to construct and validate the content of an inventory of ethical problems experienced by nurses in mobile pre-hospital care.
Method: a psychometric approach study, developed with the following stages: (1) instrument construction through a theoretical matrix based on deliberative bioethics, scoping review and online qualitative research; (2) content validity by judges; (3) pre-testing with Mobile Emergency Care Service nurses in various Brazilian states. For content validity analysis, the Content Validity Ratio was calculated (CVR>0.
Rev Bras Enferm
January 2025
Universidade Federal do Rio de Janeiro. Rio de Janeiro, Rio de Janeiro, Brazil.
Objectives: to identify how first-year nursing students use cyberspace and propose an orientation guide with criteria guiding the use of cyberspace.
Methods: qualitative and descriptive research, carried out with 24 nursing students from a federal public institution in Rio de Janeiro. Data collection was carried out through semi-structured interviews.
Rev Bras Enferm
January 2025
Universidade Federal de Santa Catarina. Florianópolis, Santa Catarina, Brazil.
Objective: to analyze how motherhood is expressed in female prison units from the perspective of Bioethics of Protection.
Method: qualitative research with an ethnographic approach, developed in two women's prison units. Participantes were: six mothers deprived of liberty, 15 health professionals, and nine prison officers.
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