Background And Purpose: Stereotactic body radiotherapy (SBRT) has been proven to be beneficial for several disease sites in the (lower) abdomen. However, the quality of the treatment plan, based on a single planning computed tomography (CT), can be compromised due to large inter-fraction motion of the target and organs at risk (OARs) in this anatomical region. The aim of this study was to investigate the feasibility of online adaptive SBRT treatments on a robotic radiosurgery system and to record estimated total treatment times.
Materials And Methods: For two disease sites, locally advanced pancreatic cancer (LAPC) and oligometastatic lymph nodes, four patients with repeat CTs were included in the feasibility study. Quick treatment plan templates were generated based on the planning CT and validated by running them on the plan and fraction CTs. For two cases a dummy run was performed and the individual steps were timed. Dose delivery was the largest contributor to the total treatment time, followed by contour adaptation.
Results: Running the quick plan templates resulted in plans similar to unrestricted plans, obeying the OAR constraints. The dummy runs showed that online adaptive treatments were completed in 64 to 83 min respectively for oligometastases and LAPC, comparable to other clinically available solutions.
Conclusions: This study showed the feasibility of online re-planning for two challenging disease sites within a clinically acceptable time frame on a robotic radiosurgery system, making use of commercially available elements that are not integrated by the vendor.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344339 | PMC |
| http://dx.doi.org/10.1016/j.phro.2022.07.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The healing power of transcutaneous electrical nerve stimulation: a systematic review on its effects after breast surgery.
Support Care Cancer
January 2025
Department of Internal Nursing, Faculty of Health Sciences, Erciyes University, Kayseri, Turkey.
Background: Transcutaneous electrical stimulation after breast cancer surgery has been utilized for various purposes, but the full efficacy of this treatment approach on postoperative symptoms remains unclear.
Aim: This study aimed to answer the question: Does transcutaneous electrical nerve stimulation significantly impact postoperative patient outcomes in individuals undergoing breast cancer surgery?
Methods: A systematic review of randomized controlled trials was conducted. Because of the limited number of studies included, it was not feasible to perform a meta-analysis.
Design of INSPIRE: Evaluation of the effectiveness of practice facilitation on implementation of screening, brief interventions, referral to treatment and medication for unhealthy alcohol use identification and treatment in primary care.
Contemp Clin Trials Commun
February 2025
Department of Medicine, Division of General Internal Medicine and Center for Health Information Partnerships, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, USA.
Background: Unhealthy alcohol use is a leading cause of preventable mortality and a risk factor for an array of social and health problems. The Intervention in Small primary care Practices to Implement Reduction in unhealthy alcohol use (INSPIRE) study is part of a nationwide campaign to improve the identification and treatment of patients engaging in unhealthy alcohol use.
Methods: We conducted a single arm, pragmatic study consisting of seventeen primary care practices in the Chicago metropolitan area, Wisconsin, and California across two waves with a 6-month latent period, a 12-month intervention period, followed by a 6-month sustainability period.
Support groups for family members of older adults in residential aged care: A pilot feasibility study.
Australas J Ageing
January 2025
Department of Psychological Sciences, Swinburne University, Melbourne, Victoria, Australia.
Objectives: There are limited mental health support services in Australia that address the well-being of family members of aged care residents. The aim of this project was to evaluate the feasibility, acceptability and preliminary effectiveness of an online program designed to support residents' families.
Methods: This one-arm mixed methods project examined uptake, attendance and retention patterns, satisfaction and experience with the service, and pre- and postoutcomes with respect to depressive and anxiety symptoms and loneliness.
Cognitive Behavioural Therapy to Optimize Post-Operative Recovery (COPE): a randomized controlled feasibility trial in extremity fracture patients.
Pilot Feasibility Stud
January 2025
Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Article Synopsis
- The study aimed to assess the feasibility of an online cognitive behavioral therapy (CBT) program for patients recovering from extremity fractures compared to usual care.
- Despite enrolling 94 participants, recruitment showed a "yellow light," indicating some success but needing improvements.
- Compliance with the CBT program was low, as only 60% completed all modules, leading to a "red light," suggesting significant changes are necessary before a larger trial can proceed.
A Scalable Approach to Internet of Things and Industrial Internet of Things Security: Evaluating Adaptive Self-Adjusting Memory K-Nearest Neighbor for Zero-Day Attack Detection.
Sensors (Basel)
January 2025
African Centre of Excellence for Internet of Things, University of Rwanda, Kigali P.O. Box 4285, Rwanda.
The Internet of Things (IoT) and Industrial Internet of Things (IIoT) have drastically transformed industries by enhancing efficiency and flexibility but have also introduced substantial cybersecurity risks. The rise of zero-day attacks, which exploit unknown vulnerabilities, poses significant threats to these interconnected systems. Traditional signature-based intrusion detection systems (IDSs) are insufficient for detecting such attacks due to their reliance on pre-defined attack signatures.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!