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COVID-19 Vaccination and Remdesivir are Associated With Protection From New or Increased Levels of Donor-Specific Antibodies Among Kidney Transplant Recipients Hospitalized With COVID-19. | LitMetric

AI Article Synopsis

  • - The study examined 112 kidney transplant patients who were hospitalized due to COVID-19 and found a 17% incidence of new or increased donor-specific antibodies (DSA) within 8 months post-infection, which can lead to allograft dysfunction.
  • - Factors contributing to increased DSA responses included the presence of pre-existing DSA and the time since transplantation, while prior COVID-19 vaccination and the use of remdesivir were linked to a lower risk of such responses.
  • - Findings indicate that monitoring for DSA changes, alongside vaccination and antiviral treatments, could be critical for preventing alloimmune reactions in kidney transplant patients suffering from COVID-19.

Article Abstract

Alloimmune responses in kidney transplant (KT) patients previously hospitalized with COVID-19 are understudied. We analyzed a cohort of 112 kidney transplant recipients who were hospitalized following a positive SARS-CoV-2 test result during the first 20 months of the COVID-19 pandemic. We found a cumulative incidence of 17% for the development of new donor-specific antibodies (DSA) or increased levels of pre-existing DSA in hospitalized SARS-CoV-2-infected KT patients. This risk extended 8 months post-infection. These changes in DSA status were associated with late allograft dysfunction. Risk factors for new or increased DSA responses in this KT patient cohort included the presence of circulating DSA pre-COVID-19 diagnosis and time post-transplantation. COVID-19 vaccination prior to infection and remdesivir administration during infection were each associated with decreased likelihood of developing a new or increased DSA response. These data show that new or enhanced DSA responses frequently occur among KT patients requiring admission with COVID-19 and suggest that surveillance, vaccination, and antiviral therapies may be important tools to prevent alloimmunity in these individuals.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343962PMC
http://dx.doi.org/10.3389/ti.2022.10626DOI Listing

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