AI Article Synopsis
- This study examines how genetic variations might influence the risk of contracting SARS-CoV-2 and the severity of COVID-19 among the Chinese population.
- Researchers analyzed data from 256 people, including those who were symptomatic, asymptomatic, and close contacts of confirmed cases, focusing on over 100,000 single-nucleotide polymorphisms.
- Key findings revealed that specific genes (like POLR2A) are linked to susceptibility to the virus, while other genetic variants were associated with the severity of the illness, providing insights that could inform future treatments and understanding of the disease.
Article Abstract
Coronavirus disease 2019 (COVID-19) is a global public health concern. The purpose of this study was to investigate the association between genetic variants and SARS-CoV-2 infection and the COVID-19 severity in Chinese population. A total of 256 individuals including 87 symptomatic patients (tested positive for SARS-CoV-2), 84 asymptomatic cases, and 85 close contacts of confirmed patients (tested negative for SARS-CoV-2) were recruited from February 2020 to May 2020. We carried out the whole exome genome sequencing between the individuals and conducted a genetic association study for SARS-CoV-2 infection and the COVID-19 severity. In total, we analyzed more than 100,000 single-nucleotide polymorphisms. The genome-wide association study suggested potential correlation between genetic variability in POLR2A, ANKRD27, MAN1A2, and ERAP1 genes and SARS-CoV-2 infection susceptibility. The most significant gene locus associated with SARS-CoV-2 infection was located in POLR2A (p = 5.71 × 10). Furthermore, genetic variants in PCNX2, CD200R1L, ZMAT3, PLCL2, NEIL3, and LINC00700 genes (p < 1 × 10) were closely associated with the COVID-19 severity in Chinese population. Our study confirmed that new genetic variant loci had significant association with SARS-CoV-2 infection and the COVID-19 severity in Chinese population, which provided new clues for the studies on the susceptibility of SARS-CoV-2 infection and the COVID-19 severity. These findings may give a better understanding on the molecular pathogenesis of COVID-19 and genetic basis of heterogeneous susceptibility, with potential impact on new therapeutic options.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9362144 | PMC |
| http://dx.doi.org/10.1007/s10096-022-04478-5 | DOI Listing |
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