AI Article Synopsis
- - This study explores the genetic factors contributing to healthy aging in an under-researched East-Asian population, focusing on Singapore Chinese elderly participants aged 65 and older.
- - Researchers conducted a genome-wide association study comparing genetic data from 1,618 healthy agers to 6,221 non-healthy agers over a 20-year period, revealing two significant genetic variants linked to healthy aging.
- - One of the identified variants is located in the LRP1B locus, known for its association with long-lived individuals who do not experience cognitive decline, enhancing understanding of genetics in healthy aging.
Article Abstract
The genetic basis of overall healthy ageing, especially among the East-Asian population is understudied. We conducted a genome-wide association study among 1618 Singapore Chinese elderly participants (65 years or older) ascertained to have aged healthily and compared their genome-wide genotypes to 6221 participants who did not age healthily, after a 20-year follow-up. Two genetic variants were identified (P < 2.59 × 10) to be associated with healthy aging, including the LRP1B locus previously associated in long-lived individuals without cognitive decline. Our study sheds additional insights on the genetic basis of healthy ageing.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9158790 | PMC |
| http://dx.doi.org/10.1038/s41514-022-00086-x | DOI Listing |
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