AI Article Synopsis
- Tibetans, living primarily in high-altitude regions of China and the Himalayas, exhibit unique genetic traits that help them adapt to low oxygen levels, making them interesting for medical and genetic research.
- A study genotyped 549 individuals using the Investigator Argus X-12 Kit, discovering 174 unique alleles and finding that specific loci (DXS10134 and DXS10135) showed significant variation.
- The analysis revealed a high diversity of haplotypes among Highlander Tibetan males and established strong discrimination power for both genders, providing valuable data for forensic and population genetic studies.
Article Abstract
Tibetans are considered an East Asian ethnic group and primarily live in the high Tibetan plateau, the western Sichuan and Yunnan mountains of central and southern China, and areas throughout the Himalayas and around the Tibetan plateau. These people exhibit rare molecular machinery that allows them to adapt to hypoxic environments in the Qinghai-Tibet Plateau and make them a potential candidate for providing insights related to medical genetic, molecular medicine and human population studies. In the current study, we have genotyped 549 individuals with Investigator Argus X-12 Kit. For 12 X-STRs, a total of 174 unique alleles were found, among them DXS10134 and DXS10135 were the most polymorphic loci. All of the loci were in Hardy-Weinberg Equilibrium (HWE). The numbers of observed haplotypes in Highlander Tibetans males were 161,112, 96 and 108, respectively, whereas haplotype diversities (HD) were 0.9959, 0.9880, 0.9809 and 0.9873, respectively. The combined discrimination power for males (PDm) was 0.999 999 99701 and for females (PDf) was 0.999 999 999 999 9958. This study represents an extensive report on X chromosomal STR markers variation in the Highlander Tibetans population for forensic applications and population genetic studies.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352086 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0271769 | PLOS |
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