AI Article Synopsis
- Atherosclerosis is a major health issue worldwide, contributing to high rates of illness and death.
- Mice are commonly used in research to understand the causes and mechanisms of atherosclerosis, with the aorta and cross-sections of the aortic root being the main methods for measuring severity.
- This review highlights the strengths and weaknesses of these methods and offers improvements to make quantification more reliable in preclinical studies.
Article Abstract
Atherosclerosis is a leading cause of morbidity and mortality in many countries. Mice are the most frequently used animal model to study the pathogenesis and molecular mechanisms of atherosclerosis. analyses of the aorta and cross-sections of the aortic root are the two common modes for quantifying the severity of atherosclerosis in mice. This mini-review introduces these two methods, discusses their pros and cons, and provides suggestions to optimize the quantification of atherosclerosis, thereby enhancing rigor and reproducibility in preclinical research.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345319 | PMC |
| http://dx.doi.org/10.36922/gtm.v1i1.76 | DOI Listing |
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