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Comprehensive Blood Metabolome and Exposome Analysis, Annotation, and Interpretation in E-Waste Workers.
Metabolites
December 2024
Faculty of Agricultural and Environmental Sciences, McGill University, Ste-Anne-de-Bellevue, QC H9X 3V9, Canada.
Electronic and electrical waste (e-waste) production has emerged to be of global environmental public health concern. E-waste workers, who are frequently exposed to hazardous chemicals through occupational activities, face considerable health risks. To investigate the metabolic and exposomic changes in these workers, we analyzed whole blood samples from 100 male e-waste workers and 49 controls from the GEOHealth II project (2017-2018 in Accra, Ghana) using LC-MS/MS.
View Article and Find Full Text PDFDynamic human gut microbiome and immune shifts during an immersive psychosocial intervention program.
Brain Behav Immun
December 2024
Department of Genetics, Stanford University School of Medicine, CA, USA; Stanford Center for Genomics and Personalized Medicine, Stanford University School of Medicine, CA, USA; Stanford Healthcare Innovation Lab, Stanford University, CA, USA. Electronic address:
Background: Although depression is a leading cause of disability worldwide, the pathophysiological mechanisms underlying this disorder-particularly those involving the gut microbiome-are poorly understood.
Method: To investigate, we conducted a community-based observational study to explore complex associations between changes in the gut microbiome, cytokine levels, and depression symptoms in 52 participants (M = 49.56, SD = 13.
Exposome Determinants of Quality of Life in Adults Over 50: Personality Traits, Childhood Conditions, and Long-Term Unemployment in SHARELIFE Retrospective Panel.
Psychol Res Behav Manag
December 2024
Department of Social and Organizational Psychology, National University for Distance Education (UNED), Madrid, 28040, Spain.
Introduction: The present research applies the exposome approach for understanding Quality of life of +50 Europeans based on retrospective panel data. Our paper explores the cumulative influences of personality traits, childhood adversities, such as poor health in infancy, culturally deprived environments, poor mathematical performance, or reduced language skills, and undesired employment status along the life course on Quality of Life of +50 Europeans.
Methods: The study utilizes data from the SHARE (Survey of Health, Aging and Retirement in Europe), belonging to SHARELIFE (wave 3 and 7) and from the Working Life Histories retrospective panel (N = 5884).
Large-scale georeferenced neuroimaging and psychometry data link the urban environmental exposome with brain health.
Environ Res
December 2024
LREN, Centre for Research in Neurosciences, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Neurology Department and Institute for Diagnostic and Interventional Neuroradiology, Inselspital, University of Bern, Bern, Switzerland; Neurology Department, Max-Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. Electronic address:
In face of cumulating evidence about the impact of human-induced environmental changes on mental health and behavior, our understanding of the main effects and interactions between environmental factors - i.e., the exposome and the brain - is still limited.
View Article and Find Full Text PDFThe World Trade Center exposome and health effects in 9/11 rescue and recovery workers.
Commun Med (Lond)
December 2024
Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Background: In the aftermath of the World Trade Center (WTC) attack on 11 September 2001, rescue and recovery workers faced hazardous conditions and toxic agents. Prior research linked these exposures to adverse health effects, but mainly examined individual factors, overlooking complex mixture effects.
Methods: This study applies an exposomic approach encompassing the totality of responders' experience, defined as the WTC exposome.
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