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Impact of long-term N-acetylcysteine use on cancer risk.
Am J Cancer Res
February 2025
Graduate Institute of Business Administration, College of Management, Fu Jen Catholic University Taipei, Taiwan.
Chronic obstructive pulmonary disease (COPD) patients face an increased risk of developing various malignancies due to shared risk factors and underlying systemic inflammation. N-acetylcysteine (NAC) has shown potential anticancer properties in preclinical studies, but clinical evidence in COPD patients is limited. We conducted a nationwide propensity score-matched cohort study using data from Taiwan's National Health Insurance Research Database to evaluate the anticancer effects of NAC in COPD patients.
View Article and Find Full Text PDFRadiotherapy can significantly improve survival outcomes in patients with muscle-invasive bladder cancer who are unsuitable for cystectomy or chemoradiotherapy.
Am J Cancer Res
February 2025
Department of Radiation Oncology, Chi Mei Medical Center No. 901, Zhonghua Road, Yung Kang District, Tainan, Taiwan.
Radical cystectomy and bladder preservation therapy are effective for muscle-invasive bladder cancer (MIBC); however, many patients over 70 are medically unfit for these options. For such patients, radiotherapy serves as a viable alternative. This study compares survival outcomes of radiotherapy versus supportive care in MIBC patients ineligible for cystectomy or bladder preservation with concurrent chemoradiotherapy.
View Article and Find Full Text PDFIncreased sputum peripheral helper T cells are associated with the severity of rheumatoid arthritis but not with the severity of airway disease.
Front Immunol
March 2025
Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Objective: Peripheral helper T (Tph) cells, together with plasma cells, are the major pathogenic lymphocytes in the synovium in rheumatoid arthritis (RA). However, whether these cells are involved in RA-associated lung and/or airway disease is unknown.
Methods: Tph cells in sputum were analyzed by flow cytometry and compared with those in synovial fluid and synovial tissue.
Prediction of ipsilateral and contralateral pneumothorax using a simple chest X-ray.
J Thorac Dis
February 2025
Department of Anesthesiology and Pain Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Republic of Korea.
Background: Accurate prediction is essential for the effective management of spontaneous pneumothorax (SP). To improve prediction, this study primarily focuses on using simple chest X-rays to predict ipsilateral recurrence and contralateral occurrence of SP.
Methods: All consecutive subjects diagnosed with SP from July 2017 to June 2023 were retrospectively reviewed.
Random forest for dynamic risk prediction of recurrent events: a pseudo-observation approach.
Biostatistics
December 2024
Department of Biostatistics, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109, United States.
Recurrent events are common in clinical, healthcare, social, and behavioral studies, yet methods for dynamic risk prediction of these events are limited. To overcome some long-standing challenges in analyzing censored recurrent event data, a recent regression analysis framework constructs a censored longitudinal dataset consisting of times to the first recurrent event in multiple pre-specified follow-up windows of length $ \tau $(XMT models). Traditional regression models struggle with nonlinear and multiway interactions, with success depending on the skill of the statistical programmer.
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