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A statistical framework for analysis of trial-level temporal dynamics in fiber photometry experiments.
Elife
March 2025
Machine Learning Core, National Institute of Mental Health, Bethesda, United States.
Fiber photometry has become a popular technique to measure neural activity in vivo, but common analysis strategies can reduce the detection of effects because they condense signals into summary measures, and discard trial-level information by averaging . We propose a novel photometry statistical framework based on functional linear mixed modeling, which enables hypothesis testing of variable effects at , and uses trial-level signals without averaging. This makes it possible to compare the timing and magnitude of signals across conditions while accounting for between-animal differences.
View Article and Find Full Text PDFA Single-Center Case-Control Study of Glaucoma Severity on Initial Presentation in Haitian Americans.
Clin Ophthalmol
March 2025
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Purpose: To assess relative glaucoma severity between Haitians and non-Haitians upon presentation to a tertiary referral practice using a retrospective case-control design.
Patients And Methods: All Haitian descent patients were age- and zip code-matched with non-Haitian Hispanic American controls from a tertiary glaucoma service in a 1:1 ratio. Clinical and social vulnerability characteristics were analyzed for differences in functional and structural glaucoma deficits.
What about anterior endocrowns?
Evid Based Dent
March 2025
Edinburgh Dental Institute Paediatric Department 39x Lauriston Building, Edinburgh, UK.
A Commentary On: Fehrenbach J, de Soares J L S, do Nascimento Foly J C S, Miotti L L, Münchow E A Mechanical performance of endocrown restorations in anterior teeth: A systematic review and network meta-analysis. Dent Mater 2025; https://doi.org/10.
View Article and Find Full Text PDFEnhancing therapeutic efficacy of Fingolimod via Intranasal Delivery in an Ethidium Bromide-induced Model of Multiple Sclerosis.
J Neurosci Methods
March 2025
Lloyd Institute of Management & Technology, Plot No -11, Knowledge Park-II, Greater Noida, Uttar Pradesh, 201306, India.
Background: Multiple sclerosis (MS) is a chronic inflammatory autoimmune neurological characterized by muscle weakness, numbness, tingling, vision problems, and difficulty in coordination and balance caused by the damage of myelin content around the nerve fibres. The recent literature is evident that along with their lymphocyte attack prevention mechanism, fingolimod (FNG) can serve as neuroprotective also by ensuring their improved brain availability. Therefore, in this project brain availability of FNG was enhanced by delivering the FNG in the form of nanoparticles.
View Article and Find Full Text PDFSpecial Diets and Nutrient Intakes in Morbidly Obese US Adults in Comparison to the 2020-2025 Dietary Guidelines for Americans.
Nutr J
March 2025
Department of Internal Medicine II, Centre for Complementary Medicine, Medical Center, Faculty of Medicine, University of Freiburg, University of Freiburg, Freiburg, Germany.
Background: Morbid Obesity (MO), defined by a Body Mass Index (BMI) > 40 kg/m, is the most severe form of obesity. The risk of suffering from any chronic medical condition is almost twice as high in MO as compared to overweight. Despite obesity being one of the most serious contemporary public health concerns, there is a paucity of nutrient intake data in adults with MO.
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