Aim: To study the impact of the prosthesis motility on the Quality of Life (QoL) in anophthalmic patients.
Methods: Cross-sectional, observational study of 100 anophthalmic patients, of whom 64% had an acryl implant, 6% an Allen implant, 1% a hydroxyapatite implant, 4% a dermis fat graft, 16% no implant, and 9% an unknown implant. We quantitatively assessed the motility of the prosthesis with Kestenbaum glasses and the QoL with a validated questionnaire covering five domains: General functional abilities and care, wearing comfort, physical appearance, psychological and social functioning. Associations between measured prosthetic eye motility, patient-perceived motility, and satisfaction were made.
Results: Motility of the prosthesis was impaired with an average loss of 76%, and correlated with Cosmetic satisfaction (adduction = .02, abduction = .008, elevation = .04) and Social satisfaction (adduction = .03, abduction = .003). The patient-perceived motility of the prosthesis correlated with General functioning abilities (horizontal = .0004, vertical = .0004), Comfort (horizontal = .001, vertical = .003), Cosmetic satisfaction (horizontal = .0002, vertical = .0002), Psychological satisfaction (horizontal = .001, vertical = .001), and Social satisfaction (horizontal = .002, vertical = .003).
Conclusions: Ocular prosthetic motility has a significant impact on patient-perceived satisfaction and physical appearance, and predicts coping with the prosthetic condition on the psychosocial level. This highlights the need of introducing patient-reported outcome measures in the prosthetic rehabilitation of the anophthalmic patient.
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http://dx.doi.org/10.1080/01676830.2022.2107687 | DOI Listing |
Indian J Ophthalmol
February 2025
Department of Ophthalmology, Faculty of Medicine, Fayoum University, Al Fayoum, Egypt.
Purpose: There are no universally established guidelines for material selection in orbital wall fracture reconstruction. With an increasing preference for permanent implants, this study aimed to compare the long-term clinical outcomes of three different non-resorbable materials in reconstructing isolated orbital floor fractures.
Design: A retrospective, interventional comparative study.
Am J Transl Res
November 2024
Department of Ophthalmology, Bethune International Peace Hospital Shijiazhuang 050082, Hebei, China.
Biomaterials
May 2025
Department of Regenerative Medicine, College of Medicine, Soonchunhyang University, Cheonan, South Korea; Institute of Tissue Regeneration, Soonchunhyang University, Cheonan, South Korea. Electronic address:
Chronic kidney disease (CKD) is a prevalent global health issue, primarily caused by glomerular dysfunction, diabetes, endovascular disorders, hypertensive nephrosclerosis, and other vascular diseases. Despite the increase in available organ sources, significant challenges remain in securing organ compatibility, prompting extensive research into creating a bio-artificial kidney free from immune rejection. In this study, a bio-engineered kidney was established using a stem cell chemoattractant within a bioreactor system; rBMSCs were used to recellularize the decellularized kidney scaffold coated with SDF-1α/AKI-CKD cytokine juice under mimic-hypoxic conditions as these chemokines and cytokines are crucial for the cell migration.
View Article and Find Full Text PDFBiomed Mater
December 2024
Laboratory of Key Technology and Materials in Minimally Invasive Spine Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
It is crucial for the successful transplantation of large segmental bone defects to achieve rapid vascularization within bone scaffolds. However, there are certain limitations including uncontrolled angiogenesis and inadequate vascular function. Therefore, there is an urgent need to develop bone scaffolds with functional vascular networks.
View Article and Find Full Text PDFInt J Pharm
January 2025
Byers Eye Institute, Department of Ophthalmology at Stanford University School of Medicine, Palo Alto 94304, CA, USA; VA Palo Alto Health Care System, Palo Alto 94304, CA, USA; Department of Chemical Engineering, Stanford University, Stanford 94305, CA, USA. Electronic address:
Electrospun gelatin nanofibers coated with hyaluronic acid (GelNF-HA) were synthesized as a scaffold for delivering human corneal mesenchymal stromal cells (C-MSCs) directly to deep corneal injuries. Aligned GelNFs were produced by electrospinning, crosslinked using vapor of glutaraldehyde, coated with HA, and crosslinked with EDC/NHS. The GelNF-HA was characterized by SEM, mechanical, and optical properties.
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