Objective: To investigate the association between thromboxane A synthase 1 () gene polymorphism and metabolic syndrome (MS) and explore whether gene polymorphism could act as biomarkers in MS and its components or whether it could play a role in MS-related damage.
Methods: A total of 3072 eligible subjects were obtained, of which 1079 cases were controls and 1993 cases were MS patients. Subjects were followed up for 5 years, and the endpoint were recorded. The gene polymorphism of was detected by using the Sequenom MassArray method.
Results: Significant differences were observed in ischemic stroke and NC_000007.14: g.139985896C>T ( < 0.05). The incidence of ischemic stroke was significantly higher in T allele carriers than in C ( < 0.05). C allele was the protective factor of the onset of ischemic stroke. There were negative interactions between C allele and waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and fasting plasma glucose (FPG).
Conclusion: These findings suggest that NC_000007.14: g.139985896C>T was related to the incidence of ischemic stroke in the whole and MS population, and individuals who carry the C allele have a reduced risk of ischemic stroke, which may be used as a promising biomarker of disease risk in patients with MS.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343182 | PMC |
| http://dx.doi.org/10.1155/2022/9717510 | DOI Listing |
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