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Global, regional, and national epidemiology of hepatoblastoma in children from 1990 to 2021: a trend analysis.
Hepatol Int
November 2024
Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China.
Background And Purpose: Hepatoblastoma is the most common primary liver cancer in children, yet comprehensive understanding of its epidemiology is limited globally. We aimed to estimate the global trend of hepatoblastoma in children from 1990 to 2021.
Methods: We collected data on hepatoblastoma in children aged 0 to 10 years from 1990 to 2021, derived from Global Burden of Disease (GBD) 2021.
ADULT-TO-PEDIATRIC LIVING DONOR LIVER TRANSPLANT IN RECIPIENTS >20 KG: A CASE SERIES OF FULL LEFT LOBE GRAFTS.
Arq Bras Cir Dig
October 2024
Pontificia Universidade Catolica do Chile, Department of Digestive Surgery, Hepato-Pancreato-Biliary Surgery Division - Santiago, Chile.
Background: Chile presents one of the lowest organ donation rates, resulting in pediatric liver waitlist mortality rates up to 38.1%. Live donor liver transplantation is one of the main alternatives to decrease waitlist mortality, mostly utilized in our country for small children up to 20 kg.
View Article and Find Full Text PDF[Ga]Ga-RAYZ-8009: A Glypican-3-Targeted Diagnostic Radiopharmaceutical for Hepatocellular Carcinoma Molecular Imaging-A First-in-Human Case Series.
J Nucl Med
October 2024
Radiology and Nuclear Medicine, UMC Utrecht, Utrecht, The Netherlands;
To date, the imaging and diagnosis of hepatocellular carcinoma (HCC) rely on CT/MRI, which have well-known limitations. Glypican-3 (GPC3) is a cell surface receptor highly expressed by HCC but not by normal or cirrhotic liver tissue. Here we report initial clinical results of GPC3-targeted PET imaging with [Ga]Ga-DOTA-RYZ-GPC3 (RAYZ-8009), a peptide-based GPC3 ligand in patients with known or suspected HCC.
View Article and Find Full Text PDFClinical Characteristics and Outcomes of Neonatal Hepatoblastoma: A Single Center Study.
J Pediatr Surg
November 2024
Department of General Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. Electronic address:
Article Synopsis
- Neonatal hepatoblastoma (HB), diagnosed within the first month of life, presents unique challenges in treatment and prognosis, prompting a study to analyze its diagnosis, treatment, and outcomes at a single center.
- The study observed 79 patients under one year old, identifying 14 with neonatal HB, which exhibited distinct clinical features such as smaller tumor size and higher tumor grades compared to non-neonatal cases, along with significantly elevated AFP levels.
- Results indicated a 100% three-year survival rate and event-free survival for neonatal HB patients, demonstrating that combined treatment strategies of surgery and chemotherapy can be highly effective, warranting further research in larger populations.
Construction and validation of nomogram prognostic model for predicting survival in hepatoblastoma patients: a population-based study.
Updates Surg
August 2024
Department of Pediatric Surgery, Tianjin Medical University General Hospital, Tianjin, China.
For patients with hepatoblastoma (HB), current staging system is not accurate in predicting survival outcomes. The aim of this study was to develop two accurate survival prediction models to guide clinical decision making. A retrospective analysis of 424 HB patients was performed from 2004 to 2015 using the Surveillance, Epidemiology and End Results (SEER) database.
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