A series of eleven 5-substituted-indole nucleoside residues were synthesized and incorporated into 15-mer oligodeoxynucleotide duplexes with each of the four natural bases (A, G, C, T) paired with the non-natural residues. The universal base properties of these residues were evaluated by comparing the stabilities of these complexes determined by UV thermal denaturation experiments. All of the substituted indoles were more stable than an unsubstituted indole residue, and measures of electronic influences of substituents on the indole pi system correlate with stability. Several residues were more promiscuous than the previously studied 5-nitroindole residue, but the relationship between substituents and selectivity is not clear.
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http://dx.doi.org/10.1080/15257770.2022.2105354 | DOI Listing |
Dalton Trans
January 2025
Department of Chemistry, St Berchmans College (Autonomous), Changanassery, Kerala, 686101, India.
This computational study investigated the catalytic efficiency of novel RhCp complexes (X = CF, SiF, CCl, SOH) in [3 + 2] azide-alkyne cycloaddition reactions density functional theory (MN12-L/Def2-SVP). Through quantum mechanical approaches, we explore the impact of different substituents on the Cp* ligand on the mechanism, selectivity, and reactivity of these Rh-based catalysts. Non-covalent interaction (NCI) and reduced density gradient (RDG) analyses, along with frontier molecular orbital (FMO) and Hirshfeld atomic charge analyses, were utilized to assess ligand stability and catalytic performance.
View Article and Find Full Text PDFBull Environ Contam Toxicol
January 2025
College of Environmental Science and Engineering, Donghua University, Shanghai, 201620, China.
Ionic liquids (ILs) are widely used "green solvent" as they have a low vapor pressure and can replace volatile solvents in industry. However, ILs are difficult to biodegrade and are potentially harmful to the environment. This study, herein, investigated the toxicity of three imidazole ILs ([CMIM]Cl, [CMIM]Br, and [CDMIM]Br) towards soil microorganisms.
View Article and Find Full Text PDFChemistry
January 2025
The University of Electro-Communications: Denki Tsushin Daigaku, Department of Engineering Science, JAPAN.
(6,5)-enriched single-walled carbon nanotubes (SWCNTs) were reductively arylated using sodium naphthalenide and monosubstituted and disubstituted iodobenzene derivatives to control their photoluminescence (PL) properties. In the reactions with substituted iodobenzenes, the degree of functionalization was influenced by the substituents on the aryl groups depending on their position, which allowed us to realize control of the PL intensity. The substituents at the 2-position and methyl groups at the 3,5-positions of the phenyl group respectively increased the E11** PL and E11* PL selectivity at ~1230 and ~1100 nm.
View Article and Find Full Text PDFACS Environ Au
January 2025
Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dübendorf, Switzerland.
Organic micropollutants, including pharmaceuticals, personal care products, pesticides, and food additives, are widespread in the environment, causing potentially toxic effects. Human waste is a direct source of micropollutants, with the majority of pharmaceuticals being excreted through urine. Urine contains its own microbiota with the potential to catalyze micropollutant biotransformations.
View Article and Find Full Text PDFJ Am Chem Soc
January 2025
Department of Chemistry and Biochemistry, Montana State University, Bozeman, Montana 59717, United States.
Under most conditions, 2,4-dihalopyrimidines undergo substitution reactions at C4. Here we report that Pd(II) precatalysts supported by bulky -heterocyclic carbene ligands uniquely effect C2-selective cross-coupling of 2,4-dichloropyrimidine with thiols. The regioselectivity of this reaction stands in stark contrast to ∼1500 previously reported Pd-catalyzed cross-couplings that favor C4 in the absence of other substituents on the pyrimidine ring.
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