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Review of current and emerging estrogen receptor agonists for vaginal atrophy.
Expert Opin Pharmacother
January 2025
Femicare vzw, Tienen, Belgium.
Introduction: Vulvovaginal atrophy (VVA) predominantly affects postmenopausal women due to hormonal decline but can also occur in premenopausal women with conditions such as primary ovarian insufficiency or exposure to anti-estrogen medications. Contributing factors include smoking and certain medical treatments. Symptoms like dyspareunia and loss of sexual function affect many women but are underreported due to stigma and lack of awareness.
View Article and Find Full Text PDFDevelopment and Bioavailability Assessment of an Estriol-Containing Vaginal Hydrogel.
Gels
December 2024
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary.
Genitourinary syndrome of menopause (GSM) affects a significant percentage of postmenopausal women and manifests as vaginal dryness, irritation, and urinary discomfort, typically treated with vaginal estrogens. Hydrogels are preferred over creams due to their superior comfort and mucoadhesive properties. This study introduces a novel vaginal gel formulation containing hydroxyethyl cellulose (HEC) and estriol-hydroxypropyl-β-cyclodextrin complex (E3-HPBCD) for the treatment of GSM.
View Article and Find Full Text PDFDeep learning model using continuous skin temperature data predicts labor onset.
BMC Pregnancy Childbirth
November 2024
College of Nursing, The University of Arizona, Tucson, AZ, USA.
Background: Changes in body temperature anticipate labor onset in numerous mammals, yet this concept has not been explored in humans. We investigated if continuous body temperature exhibits similar changes in women and whether these changes may be linked to hormonal status. Finally, we developed a deep learning model using temperature patterning to provide a daily forecast of time to labor onset.
View Article and Find Full Text PDFExploring the impact of 3,3'-diindolylmethane on the urinary estrogen profile of premenopausal women.
BMC Complement Med Ther
November 2024
Precision Analytical, Inc., McMinnville, USA.
Background: 3,3'-diindolylmethane (DIM) is a phytonutrient derived from cruciferous vegetables that is an often-used supplement in the complementary and alternative medicine space. The most common goal for providers when recommending DIM to their patients is to alter estrogen metabolism, yet research into DIM's effect on the estrogen profile is lacking in the published literature. The objective of this study was to comprehensively evaluate DIM's effect on the urinary estrogen profile.
View Article and Find Full Text PDFEfficacy and safety of an ultra-low-dose 0.005 % estriol vaginal gel in the prevention of urinary tract infections in postmenopausal women with genitourinary syndrome of menopause: A randomized double-blind placebo-controlled trial.
Maturitas
December 2024
Medical Department, ITF Research Pharma S.L.U., Madrid, Spain.
Article Synopsis
- This study tested an ultra-low-dose estriol vaginal gel (0.005%) to see if it could prevent urinary tract infections (UTIs) in postmenopausal women with genitourinary syndrome of menopause.
- The clinical trial involved 108 women who were divided into two groups: one received the estriol gel, while the other got a placebo gel, and they were monitored for 24 weeks.
- Results showed a 26% lower rate of UTIs in the group using estriol compared to placebo, indicating the gel is both safe and effective in reducing UTI occurrences and improving vaginal health.
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