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Subacute symptoms of depression and anxiety in stress-exposed mice: Role of Schinus terebinthifolia Raddi leaf lectin (SteLL).
J Ethnopharmacol
January 2025
Biochemistry Department, Center of Biosciences, Universidade Federal de Pernambuco, Recife, Brazil; Center for Therapeutic Innovation Suely Galdino (NUPIT-SG), Universidade Federal de Pernambuco, Recife, Brazil. Electronic address:
Ethnopharmacological Relevance: Anxiety and depression are leading causes of disability worldwide, often exacerbated by chronic stress. Schinus terebinthifolia Raddi. has been used in traditional medicine for several purposes.
View Article and Find Full Text PDFDiffuse Noxious Inhibitory Controls in Chronic Pain States: Insights from Pre-Clinical Studies.
Int J Mol Sci
January 2025
Instituto de Investigação e Inovação em Saúde da Universidade do Porto-i3S, R. Alfredo Allen 208, 4200-135 Porto, Portugal.
Diffuse noxious inhibitory control (DNIC), also known as conditioned pain modulation (CPM) in humans, is a paradigm wherein the heterotopic application of a noxious stimulus results in the attenuation of another spatially distant noxious input. The pre-clinical and clinical studies show the involvement of several neurochemical systems in DNIC/CPM and point to a major contribution of the noradrenergic, serotonergic, and opioidergic systems. Here, we thoroughly review the latest data on the monoaminergic and opioidergic studies, focusing particularly on pre-clinical models of chronic pain.
View Article and Find Full Text PDFThe evaluation value of F-AV-133 PET/CT imaging in the Parkinson's disease crab-eating monkey model.
Hell J Nucl Med
December 2024
Nuclear Medicine and Radiology, Guangxi Medical University Cancer Hospital, China.
Objective: To investigate the diagnostic value of fluorine-18-9-fluoropropyl-(+)-dihydrotetrabenazine (F-AV-133) positron emission tomography/computed tomography (PET/CT) for Parkinson's disease (PD) and the metabolic parameter changes in the PD macaque model.
Subjects And Methods: Sixty three macaques were divided into an experimental group (n=55) and a normal group (n=8) for F-AV-133 PET/CT imaging. In the experimental group, the macaques were injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) solution into one side of the neck artery 2-3 months before imaging to induce unilateral striatal damage for self-control, while the normal group received no special treatment.
Clinical application of respiratory-gated auricular vagal afferent nerve stimulation.
Neuroscience
January 2025
Department of Rehabilitation, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China; Department of Rehabilitation, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, China. Electronic address:
Vagus nerve stimulation (VNS) has garnered significant attention as a promising bioelectronic therapy. In recent years, respiratory-gated auricular vagal afferent nerve stimulation (RAVANS), a novel non-invasive vagus nerve stimulation technique, has emerged. RAVANS integrates respiration with transcutaneous auricular vagus nerve stimulation (taVNS) and shares a similar mechanism of action to traditional VNS.
View Article and Find Full Text PDFIncreased dopamine D/D receptor and serotonin transporter availability in male rats after spontaneous remission from repeated social defeat-induced depression; a PET study in rats.
Neurobiol Dis
November 2024
Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713, GZ, Groningen, the Netherlands. Electronic address:
Most pharmacological treatments for depression target monoamine transporters and about 50 % of treated patients attain symptomatic remission. Once remission is attained, it is hard to distinguish the changes on brain monoaminergic transmission induced by the antidepressants, from those associated to remission per se. In this study, we aimed at studying the brain of spontaneously remitted rats from repeated social defeat (RSD)-induced depression in terms of dopamine D/D receptor and serotonin transporter (SERT) availability, showing absence of depressive symptoms 2 weeks after RSD.
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