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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997597 | PMC |
http://dx.doi.org/10.1080/13543784.2022.2108588 | DOI Listing |
Expert Opin Investig Drugs
September 2022
Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Clin Cancer Res
January 2020
Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Purpose: Advances in immunotherapy have revolutionized care for some patients with cancer. However, current checkpoint inhibitors are associated with significant toxicity and yield poor responses for patients with central nervous system tumors, calling into question whether cancer immunotherapy can be applied to glioblastoma multiforme. We determined that targeting the CD200 activation receptors (CD200AR) of the CD200 checkpoint with a peptide inhibitor (CD200AR-L) overcomes tumor-induced immunosuppression.
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