AI Article Synopsis
- - A chemical study of the herb Sch-Bip resulted in the discovery of six new compounds called Gerberdriasins A-F, identified as coumarin derivatives.
- - The structures of these compounds were analyzed using advanced techniques like NMR, mass spectroscopy, and electronic circular dichroism experiments.
- - The new compounds showed promising neuroprotective properties in lab tests, particularly against cell damage induced by scopolamine, with compound 1 also reducing cell death and improving antioxidant activity.
Article Abstract
A chemical investigation on the herb (Linn) Sch-Bip led to the isolation and identification of six previously undescribed coumarin derivatives, named Gerberdriasins A-F (1-6). Structurally, their chemical structures and absolute configurations were determined by nuclear magnetic resonance (1D and 2D NMR), high resolution electrospray ionization mass spectroscopy (HR-ESI-MS), experimental and quantum mechanical nuclear magnetic resonance (QM-NMR) methods, Mosher's method and calculated electronic circular dichroism (ECD) experiments. The biological activity of the obtained compounds showed that they displayed significant neuroprotective effects against scopolamine-induced injury in PC12 cells at the concentrations 12.5, 25.0 and 50.0 nM. Further study demonstrated that 1 could inhibit cell apoptosis, decrease malondialdehyde (MDA) levels and increase superoxide dismutase (SOD) activity in scopolamine-treated PC12 cells.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297695 | PMC |
| http://dx.doi.org/10.1039/d2ra03166c | DOI Listing |
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