AI Article Synopsis
- * Current research focuses on creating -methyl amides using a method that optimizes atom economy, addressing the challenge posed by the volatile nature of methyl amine.
- * The study presents an efficient protocol using DABCO/FeO as catalysts, which works well with various acids and achieves high yields (60-99%), while allowing for the FeO catalyst to be reused multiple times.
Article Abstract
Amide is a fundamental group that is present in molecular structures of all domains of organic chemistry and the construction of this motif with high atom economy is the focus of the current research. Specifically, -methyl amides are valuable building blocks in natural products and pharmaceutical science. Due to the volatile nature of methyl amine, the generation of -methyl amides using simple acids with high atom economy is rare. Herein, we disclose an atom economic protocol to prepare this valuable motif under DABCO/FeO cooperative catalysis. This protocol is operationally simple and compatible with a range of aliphatic and (hetero)aromatic acids with very good yields (60-99%). Moreover, the FeO can be easily recovered and high efficiency is maintained for up to ten cycles.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284536 | PMC |
| http://dx.doi.org/10.1039/d2ra03255d | DOI Listing |
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