Survivin is a component of the chromosomal passenger complex, which includes Aurora B, INCENP, and Borealin, and is required for chromosome segregation and cytokinesis. We performed a genome-wide screen of deubiquitinating enzymes for survivin. For the first time, we report that USP19 has a dual role in the modulation of mitosis and tumorigenesis by regulating survivin expression. Our results found that USP19 stabilizes and interacts with survivin in HCT116 cells. USP19 deubiquitinates survivin protein and extends its half-life. We also found that USP19 functions as a mitotic regulator by controlling the downstream signaling of survivin protein. Targeted genome knockout verified that USP19 depletion leads to several mitotic defects, including cytokinesis failure. In addition, USP19 depletion results in significant enrichment of apoptosis and reduces the growth of tumors in the mouse xenograft. We envision that simultaneous targeting of USP19 and survivin in oncologic drug development would increase therapeutic value and minimize redundancy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637645 | PMC |
| http://dx.doi.org/10.1016/j.ymthe.2022.07.019 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Diagnostic accuracy of artificial intelligence algorithms to predict remove all macroscopic disease and survival rate after complete surgical cytoreduction in patients with ovarian cancer: a systematic review and meta-analysis.
BMC Surg
January 2025
Department of Obstetrics and Gynecology, Firoozgar Clinical Research and Development Center (FCRDC), School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Background: Complete Cytoreduction (CC) in ovarian cancer (OC) has been associated with better outcomes. Outcomes after CC have a multifactorial and interrelated cause that may not be predictable by conventional statistical methods. Artificial intelligence (AI) may be more accurate in predicting outcomes.
View Article and Find Full Text PDFPsychological Interventions to Improve Elite Athlete Mental Wellbeing: A Systematic Review and Meta-analysis.
Sports Med
January 2025
School of Psychology, University of Wollongong, Wollongong, NSW, 2500, Australia.
Background: Mental wellbeing, one continuum alongside mental illness in a dual-continua mental health model, has attracted less attention compared with substantial studies concerning mental illness amongst elite athletes. Notably, the promotion and protection of mental wellbeing contribute to not only a positive status of flourishing but also a reduction in the future risk of mental illness, which can potentially facilitate a status of complete mental health. Despite the critical role of wellbeing promotion and protection, there are limited evidence-based strategies to design and implement wellbeing interventions in elite athletes.
View Article and Find Full Text PDFSmart release injectable hydrogel co-loaded with liposomal combretastatin A4 and doxorubicin nanogel for local combinational drug delivery: A preclinical study.
Int J Pharm
January 2025
Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
Surgical resection and postoperative adjuvant chemotherapy have enhanced the outlook for breast cancer patients. However, tumor relapse and serious side effects of chemotherapy continue to impact patients' quality of life. Designing injectable composite hydrogel made of biodegradable polymers providing sustained release of antiangiogenic and chemotherapeutic agents might play a vital role in elimination of cancer cells.
View Article and Find Full Text PDFInterpretable machine learning reveals transport of aged microplastics in porous media: Multiple factors co-effect.
Water Res
January 2025
School of Geography and Ocean Science, Nanjing University, Nanjing 210023, China; Key Laboratory of Coastal Zone Exploitation and Protection, Ministry of Natural Resources, Nanjing 210024, China. Electronic address:
Microplastics (MPs) easily migrate into deeper soil layers, posing potential risks to subterranean habitats and groundwater. However, the mechanisms governing the vertical migration of MPs in soil, particularly aged MPs, remain unclear. In this study, we investigate the transport of MPs under varying MPs properties, soil texture and hydrology conditions.
View Article and Find Full Text PDFExploring the impact of entrepreneurial orientation and market orientation on entrepreneurial performance in the context of environmental uncertainty.
Sci Rep
January 2025
Automotive Business School, Hubei University of Automotive Technology, Shiyan, 442000, Hubei, China.
In the current complex economic environment, entrepreneurial enterprises, as a crucial force in China's economic transformation, have vital survival and development strategies. This study is grounded in resource-based theory, integrating strategic management and contingency theories. It establishes a theoretical model based on the influence pathway of "entrepreneurial orientation-market orientation-entrepreneurial performance", incorporating environmental uncertainty as a moderating variable.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!