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| http://dx.doi.org/10.1186/s12889-022-13813-6 | DOI Listing |
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Prediction correction modeling of water-conducting fracture zones height due to repeated mining in close distance coal seams.
Sci Rep
December 2024
School of Minging and Geomatics Engineering, Hebei University of Engineering, Handan, 10076, China.
The height of the water-conducting fracture zones (WCFZ) is crucial for ensuring safe coal mining beneath aquifers, particularly considering the secondary development of the WCFZ in upper seams due to repeated mining in close distance coal seams. Accurately predicting this height is essential for mine safety, groundwater protection, and optimal coal resource use. This study compiles extensive measured data from various mining areas in China to analyze the coupling relationship between the WCFZ development height and six influencing factors: mining thickness, mining depth, coal seam spacing, hard rock lithology ratio, and the slope length of working face.
View Article and Find Full Text PDFOrthogonal and multiplexable genetic perturbations with an engineered prime editor and a diverse RNA array.
Nat Commun
December 2024
Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX, USA.
Programmable and modular systems capable of orthogonal genomic and transcriptomic perturbations are crucial for biological research and treating human genetic diseases. Here, we present the minimal versatile genetic perturbation technology (mvGPT), a flexible toolkit designed for simultaneous and orthogonal gene editing, activation, and repression in human cells. The mvGPT combines an engineered compact prime editor (PE), a fusion activator MS2-p65-HSF1 (MPH), and a drive-and-process multiplex array that produces RNAs tailored to different types of genetic perturbation.
View Article and Find Full Text PDFOptomechanical energy enhanced BF-QEPAS for fast and sensitive gas sensing.
Photoacoustics
February 2025
College of Control Science & Engineering, China University of Petroleum (East China), Qingdao 266580, PR China.
Traditional beat frequency quartz-enhanced photoacoustic spectroscopy (BF-QEPAS) are limited by short energy accumulation times and the necessity of a decay period, leading to weaker signals and longer measurement cycles. Herein, we present a novel optomechanical energy-enhanced (OEE-) BF-QEPAS technique for fast and sensitive gas sensing. Our approach employs periodic pulse-width modulation (PWM) of the laser signal with an optimized duty cycle, maintaining the quartz tuning fork's (QTF) output at a stable steady-state level by applying stimulus signals at each half-period and allowing free vibration in alternate half-periods to minimize energy dissipation.
View Article and Find Full Text PDFComparative Study of Dimeric Fibroblast Activation Protein-Targeting Radioligands Labeled with Fluorine-18, Copper-64, and Gallium-68.
Mol Pharm
December 2024
Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea.
Fibroblast activation protein inhibitors (FAPIs) labeled with gallium-68 and lutetium-177 show potential for use in the diagnosis and treatment of various cancers expressing FAP. However, Lu-labeled FAPIs often exhibit short tumor retention time, limiting their therapeutic applications. To improve tumor retention, we synthesized three radiolabeled dimeric FAPIs, [F], [Cu], and [Ga].
View Article and Find Full Text PDFCritical review of aging clocks and factors that may influence the pace of aging.
Front Aging
December 2024
Integrative Research Institute, Sacramento, CA, United States.
Background And Objectives: Aging clocks are computational models designed to measure biological age and aging rate based on age-related markers including epigenetic, proteomic, and immunomic changes, gut and skin microbiota, among others. In this narrative review, we aim to discuss the currently available aging clocks, ranging from epigenetic aging clocks to visual skin aging clocks.
Methods: We performed a literature search on PubMed/MEDLINE databases with keywords including: "aging clock," "aging," "biological age," "chronological age," "epigenetic," "proteomic," "microbiome," "telomere," "metabolic," "inflammation," "glycomic," "lifestyle," "nutrition," "diet," "exercise," "psychosocial," and "technology.
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