AI Article Synopsis
- Exosomes from human umbilical cord mesenchymal stem cells (HUMSCs) may help with inflammation in rheumatoid arthritis, as shown in mouse studies.
- Mice treated with HUMSC-derived exosomes had reduced swelling and lower levels of inflammatory markers and antibodies related to collagen.
- The study suggests that HUMSC exosomes help restore immune balance by affecting specific immune cells and cytokines, which could offer new therapeutic approaches for rheumatoid arthritis.
Article Abstract
Exosomes released by mesenchymal stem cells (MSCs) are thought to function as extensions of the MSCs. However, it remains unclear whether exosomes derived from human umbilical cord MSCs (HUMSCs) possess immunoregulatory functions in rheumatoid arthritis. We report that when mice with collagen-induced arthritis were injected with exosomes derived from HUMSC (HUMSC-Exo), their paws became less swollen, and they had lower serum pro-inflammatory cytokine and anti-collagen IgG levels, and decreased synovial hyperplasia. The HUMSC-Exo appeared to restore the balance between Th17 and Treg cells, and this effect was accompanied by reduced IL-17 and enhanced TGF-β and IL-10 levels. These findings suggest that HUMSC-Exo function as important regulator of the balance between Th1/Th17 and Treg cells during immune and inflammatory responses.
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| http://dx.doi.org/10.1002/1873-3468.14460 | DOI Listing |
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