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Congress of Neurological Surgeons systematic review and evidence-based guidelines for the role of surgery in the management of patients with diffuse low grade glioma: update.
J Neurooncol
January 2025
Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA.
Target populationAdults with imaging suggestive of a WHO grade II diffuse gliomas (oligodendrogliomas or astrocytomas)QuestionIn adults with imaging suggestive of a WHO grade II diffuse gliomas (oligodendrogliomas or astrocytomas), does surgical resection improve overall survival compared to observation or biopsy?Updated Recommendation from the Prior Version of These Guidelines:Level III: In adults with imaging suggestive of a WHO grade II diffuse gliomas (oligodendrogliomas or astrocytomas), surgical resection is suggested over observation or biopsy to improve overall survival.Question Q2In adults with imaging suggestive of a WHO grade II diffuse gliomas (oligodendrogliomas or astrocytomas), does maximal surgical resection improve progression free survival (PFS) and overall survival (OS) compared to subtotal resection/biopsy?Unchanged Recommendations from the Prior Version of These GuidelinesLevel II It is recommended that GTR or STR be accomplished instead of biopsy alone when safe and feasible so as to decrease the frequency of tumor progression recognizing that the rate of progression after GTR is fairly high.Level III Greater extent of resection can improve OS in WHO grade II diffuse gliomas patients.
View Article and Find Full Text PDFN influences on CH accumulation and displacement in shale by molecular dynamics.
Sci Rep
January 2025
School of Minerals and Energy Resources Engineering, University of New South Wales, Sydney, 2052, Australia.
N is generally employed as a displacement agent to enhance gas recovery in shale gas-bearing reservoirs. However, the primary displacement mechanism in the subsurface still needs to be clarified due to the characteristics of shale reservoirs with low porosity and abundant nanopores. This study employs the Molecular Dynamics (MD) simulation method to investigate the effects of N on the CH accumulation and displacement processes by adopting practical conditions in the subsurface environment.
View Article and Find Full Text PDFUV-irradiated BSA: The details of aggregation kinetics and structural rearrangements.
Int J Biol Macromol
January 2025
Bach Institute of Biochemistry, Federal Research Centre "Fundamentals of Biotechnology" of the Russian Academy of Sciences, Leninsky pr. 33, Moscow 119071, Russia. Electronic address:
UV-irradiation is a stress factor for proteins, leading to disruption of their native structure. Test systems based on UV-irradiated proteins are relevant for researchers, as they allow working directly with damaged protein molecules, which can be important when studying the properties and mechanisms of action of various antiaggregation agents. The study of UV-irradiated proteins can also have applied significance, including medical.
View Article and Find Full Text PDFLanthanides doped NaLaMgWO phosphors for anti-counterfeit applications.
Spectrochim Acta A Mol Biomol Spectrosc
January 2025
Department of Physics, RTM Nagpur University, Nagpur 440033 India.
Luminescence of NaLaMgWO doped with lanthanide activators Tb, Eu and Er are reported. These activators exhibit characteristic emission spectra. Either the emission colour or the excitation spectrum distinguishes between these activators.
View Article and Find Full Text PDFA case of Sjögren's syndrome with selective anion exchanger 1 defect causing distal renal tubular acidosis.
Pediatr Nephrol
January 2025
Division of Nephrology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Distal renal tubular acidosis (dRTA) is a significant clinical expression of Sjögren's syndrome (SS). While SS-related dRTA is traditionally linked to impaired H-ATPase, we report a unique case demonstrating selectively decreased anion exchanger 1 (AE1) expression with preserved H-ATPase expression. A 16-year-old girl with SS presented with muscle weakness, difficulty in ambulation, and severe hypokalemia.
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