AI Article Synopsis
- Hypertrophic cardiomyopathy (HCM) is a genetic heart condition marked by thickening of the left ventricle.
- Researchers transformed blood cells from a HCM patient into induced pluripotent stem cells (iPSC) with a specific genetic mutation.
- The created cell line (YCMi006-A) shows key stem cell characteristics and can differentiate into various cell types, making it useful for studying HCM's causes.
Article Abstract
Hypertrophic cardiomyopathy (HCM) is a common inherited cardiovascular disease and is characterized by hypertrophy of the left ventricle. We reprogrammed peripheral blood mononuclear cells (PBMCs) from a HCM patient into pluripotent stem cells (iPSC) (YCMi006-A) carrying a heterozygous c.1029C > G mutation in ACTA1. The YCMi006-A cells expressed high levels of pluripotent markers, had a normal 46XX karyotype and demonstrated the capacity to differentiate into derivatives of all three germ layers. This cell line can be a valuable tool for investigating the pathogenesis of HCM.
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| http://dx.doi.org/10.1016/j.scr.2022.102874 | DOI Listing |
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