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The Stenotrophomonas maltophilia L2 cephalosporinase is one of two beta-lactamases which afford S. maltophilia beta-lactam resistance. With the overuse of beta-lactams, selective pressures have contributed to the evolution of these proteins, generating proteins with an extended spectrum of activity.
View Article and Find Full Text PDFFine-tuning blood culture practices: implementing diagnostic stewardship in cardiothoracic surgery patients.
Interdiscip Cardiovasc Thorac Surg
January 2025
Division of Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Overusing blood cultures (BCxs) can lead to false positives, unnecessary antibiotics, and increased healthcare costs. Despite studies on inpatient BCx algorithms, none have focused on cardiothoracic surgery (CTS) patients, with complex postoperative care and invasive devices. This study aimed to evaluate the impact of a BCx algorithm on BCx event (BCE) rates in CTS step-down units.
View Article and Find Full Text PDFEvaluating the Biomechanical Effects and Real-World Usability of a Novel Ankle Exo for Runners.
J Biomech Eng
January 2025
Department of Mechanical Engineering, Vanderbilt University, 2201 West End Avenue, Nashville, TN, 37235.
Achilles tendon overuse injuries are common for long-distance runners. Ankle exos (exoskeletons and exosuits) are wearable devices that can reduce Achilles tendon loading and could potentially aid in the rehabilitation or prevention of these injuries by helping to mitigate and control tissue loading. However, most ankle exos are confined to controlled lab testing and are not practical to use in real-world running.
View Article and Find Full Text PDFEffect of Screen Time and Sugar Consumption Reduction on Sleep Bruxism in Children: A Randomised Clinical Trial.
J Oral Rehabil
January 2025
Universidad CES, Medellín, Colombia.
Objective: Sleep bruxism (SB) is associated with alterations in dopamine and serotonin, which are related to increased consumption of added sugar and overuse of screens. The aim of this study was to compare the effect of the interventions 'Food, Fun and Family' (FFF) and Counselling and Education (CE) on the frequency of SB in children.
Methods: A randomised clinical trial was conducted.
Barriers and facilitators for the implementation of delayed-prescription of antibiotics in family medicine: a qualitative study.
BMC Health Serv Res
January 2025
Faculty of Communication, Culture and Society, Università Della Svizzera Italiana, Lugano, Switzerland.
Background: Delayed prescription is a strategy used in various countries to reduce antibiotic overuse and contend the effects of antibiotic resistance; however this practice is not yet used in Switzerland. The present qualitative study was thus conducted to investigate Swiss patients' attitudes towards the possible implementation of delayed prescription.
Method: Five focus groups with the general population based on a fixed script of questions to elicit opinions on delayed prescription.
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