Regulates Bovine Myoblasts Proliferation and Differentiation via the miR-411a/ Axis.

Circular RNA (circRNA) is endogenous noncoding RNA found throughout the eukaryotic genome. It regulates several biological activities at the transcription or post-transcription level. However, the underlying function of circRNA in bovine skeletal muscle development remains unknown. Here, we identified a novel circRNA, , and investigated its function and mechanism on the proliferation and differentiation of bovine myoblasts. At the molecular and cellular levels, could promote bovine myoblasts proliferation and inhibit differentiation. Mechanistically, is expressed in the cytoplasmic of myoblast and was enriched by protein Ago2. acts as a competing endogenous RNA that sponges miR-411a and alleviates the inhibitory effect on its target gene, . miR-411a and were also involved in regulating bovine myoblast proliferation and differentiation. These findings suggest that functions as a competing endogenous RNA and regulates bovine myoblast proliferation and differentiation through the miR-411a/ axis.