AI Article Synopsis
- - Aspergillus fumigatus is the primary cause of aspergillosis, a serious fungal infection.
- - The antifungal drug caspofungin (CSP) can treat this infection, but some strains show tolerance to it.
- - The transcription factor FhdA plays a crucial role in regulating genes essential for mitochondrial function in response to CSP, revealing a new mechanism of interaction.
Article Abstract
Aspergillus fumigatus is the main etiological agent of aspergillosis. The antifungal drug caspofungin (CSP) can be used against A. fumigatus, and CSP tolerance is observed. We have previously shown that the transcription factor FhdA is important for mitochondrial activity. Here, we show that FhdA regulates genes transcribed by RNA polymerase II and III. FhdA influences the expression of tRNAs that are important for mitochondrial function upon CSP. Our results show a completely novel mechanism that is impacted by CSP.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487462 | PMC |
| http://dx.doi.org/10.1128/aac.00701-22 | DOI Listing |
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