AI Article Synopsis
- Animals exhibit defensive behaviors based on how immediate a threat is, and laboratory studies on rodents have revealed insights into the brain’s mechanisms for these responses.
- The central nucleus of the amygdala (CeA) is highlighted as playing a crucial role in managing these defensive modes through mutually inhibitory circuits that apply a "winner-takes-all" approach.
- This review suggests a new framework for understanding CeA function and outlines future research priorities to explore its effects on defensive behavior and threat association.
Article Abstract
In nature, animals display defensive behaviors that reflect the spatiotemporal distance of threats. Laboratory-based paradigms that elicit specific defensive responses in rodents have provided valuable insight into the brain mechanisms that mediate the construction of defensive modes with varying degrees of threat imminence. In this Review, we discuss accumulating evidence that the central nucleus of the amygdala (CeA) plays a key role in this process. Specifically, we propose that the mutually inhibitory circuits of the CeA use a winner-takes-all strategy that supports transitioning across defensive modes and the execution of specific defensive behaviors to previously formed threat associations. Our proposal provides a conceptual framework in which seemingly divergent observations regarding CeA function can be interpreted and identifies various areas of priority for future research.
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| http://dx.doi.org/10.1038/s41593-022-01130-5 | DOI Listing |
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