A new path for terpenoid biosynthesis.

Trends Biochem Sci

Université d'Angers, Université de Bretagne Occidentale, Institut de Recherche Fondamentale (IRF), Structure Féderative de Recherche (SFR) Interactions Cellulaires et Applications Thérapeutiques (ICAT), 49000 Angers, France. Electronic address:

Published: November 2022

Triterpenes are C30 organic compounds abundantly found in all living organisms. Although previously believed to be exclusively produced from squalene or oxidosqualene, a recent report by Tao and colleagues describes a new triterpene biosynthetic route involving the cyclization of the precursor hexaprenyl diphosphate (HexPP) by unprecedented bifunctional terpene synthase (TS) enzymes.

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Source
http://dx.doi.org/10.1016/j.tibs.2022.07.004DOI Listing

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