AI Article Synopsis
- The study explored how THC, the active component of cannabis, affects brain activation and blood flow in various regions of the brain among participants, aiming for a better understanding of its neurobiological mechanisms.
- Researchers used a repeated measures design and examined the relationship between THC effects and the presence of cannabinoid receptors (CB1R and CB2R) in specific brain areas.
- The findings indicated that THC's effects are linked to the dose administered and tend to be stronger in regions of the brain that have higher levels of CB1R, which play a role in cognitive tasks and processes.
Article Abstract
The neurobiological mechanisms underlying the effects of delta-9-tetrahydrocannabinol (THC) remain unclear. Here, we examined the spatial acute effect of THC on human regional brain activation or blood flow (hereafter called 'activation signal') in a 'core' network of brain regions from 372 participants, tested using a within-subject repeated measures design under experimental conditions. We also investigated whether the neuromodulatory effects of THC are related to the local expression of the cannabinoid-type-1 (CB1R) and type-2 (CB2R) receptors. Finally, we investigated the dose-response relationship between THC and key brain substrates. These meta-analytic findings shed new light on the localisation of the effects of THC in the human brain, suggesting that THC has neuromodulatory effects in regions central to many cognitive tasks and processes, related to dose, with greater effects in regions with higher levels of CB1R expression.
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| http://dx.doi.org/10.1016/j.neubiorev.2022.104801 | DOI Listing |
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