AI Article Synopsis
- Polycystic ovary syndrome (PCOS) is a common disorder that affects women's hormonal and metabolic health but has an unclear cause, making symptom management the primary focus of treatment.
- The text reviews current and emerging drug therapies for women with PCOS who are not trying to get pregnant, based on a literature search that included studies up to January 2022.
- Due to the diverse symptoms of PCOS, treatments must be personalized for each patient, and a deeper understanding of the disorder's molecular mechanisms could lead to the creation of more effective therapies.
Article Abstract
Introduction: Polycystic ovary syndrome (PCOS) is a common hormonal, metabolic, and reproductive disorder with a heterogeneous phenotype. As the exact etiology of PCOS is still unclear, available pharmacotherapies are mostly directed toward alleviating symptoms and associated metabolic abnormalities.
Areas Covered: Herein, we present an overview of the current and emerging pharmacotherapies for the management of women with PCOS who do not seek pregnancy. We performed a literature search in PubMed database up to January 2022 and reviewed papers assessing drug treatments for PCOS. We aimed to outline the most recent evidence to support treatment recommendations in these patients.
Expert Opinion: Targets for medical treatment include hormonal, reproductive, and metabolic abnormalities in PCOS. However, none of the available pharmacological options can cover the entire spectrum of clinical manifestations observed in these patients. Considering the heterogeneity of PCOS, treatment should be individualized and adapted to specific needs of each patient. Better understanding of the molecular mechanisms underlying the pathogenesis of PCOS would help development of novel, safer, and more effective multi-targeted therapeutic strategies for the syndrome.
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| http://dx.doi.org/10.1080/14656566.2022.2108702 | DOI Listing |
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