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Real-World Clinical Characteristics and Outcomes with Daptomycin Use in Pediatric Patients: A Retrospective Case Series.
Antibiotics (Basel)
September 2024
Department of Pharmacy Services, Medical University of South Carolina Shawn Jenkins Children's Hospital, Charleston, SC 29425, USA.
Introduction: Daptomycin (DAP) is a cyclic lipopeptide that exhibits potent in vitro activity against many drug-resistant gram-positive organisms, including methicillin-resistant (MRSA) and vancomycin-resistant enterococci (VRE). Despite substantial reports evaluating the clinical outcomes of DAP within the adult population, real-world data are lacking in children. The primary goal of this evaluation was to describe the clinical characteristics and outcomes of DAP use in pediatric patients across a wide range of infections.
View Article and Find Full Text PDFClinical Outcomes of Patients with AmpC-Beta-Lactamase-Producing Enterobacterales Bacteremia Treated with Carbapenems versus Non-Carbapenem Regimens: A Single-Center Study.
Antibiotics (Basel)
July 2024
Faculty of Medicine, Hebrew University, Jerusalem 91904, Israel.
Introduction: Bloodstream infections caused by AmpC-producing Enterobacterales pose treatment challenges due to the risk of AmpC overproduction and treatment failure. Current guidelines recommend carbapenems or cefepime as optimal therapy. We aimed to evaluate empiric and definitive non-carbapenem regimens for these infections.
View Article and Find Full Text PDFRecurrent central venous catheter infection in a five year old child on long term parenteral nutrition for short gut syndrome: could gut translocation be responsible?
Med Mycol Case Rep
September 2024
Women's and Children's Hospital, 72 King William Rd, Adelaide, 5006, Australia.
Article Synopsis
- A five-year-old girl with short gut syndrome and long-term TPN dependence experienced two non-fatal central line-associated bloodstream infections (CLABSI) over a span of 15 months, with no signs of ongoing mold infections in between the episodes.
- Both infections were managed by removing the infected central venous catheter and administering 6 weeks of antifungal treatment, leading to positive clinical outcomes.
- This case highlights the unique aspects of recurrent blood culture positive mucormycosis, suggesting that the bloodstream infections may behave differently compared to invasive mucormycosis from other fungal species.
Salvage strategy for long-term central venous catheter-associated Staphylococcus aureus infections in children: a multi-centre retrospective study in France.
J Hosp Infect
August 2024
Department of General Pediatrics and Infectious Diseases, Necker-Enfants Malades University Hospital, AP-HP, Université Paris Cité, Paris, France. Electronic address:
Objectives: Catheter removal is recommended in adults with Staphylococcus aureus central-line-associated bloodstream infection (CLABSI) but is controversial in children with long-term central venous catheters (LTCVC). We evaluated the occurrence of catheter salvage strategy (CSS) in children with S. aureus LTCVC-associated CLABSI and assessed determinants of CSS failure.
View Article and Find Full Text PDFCharacterizing Patients Presenting on Hospital Admission With Central Line-Associated Bloodstream Infections: A Multicenter Study.
Clin Infect Dis
June 2024
Johns Hopkins University School of Medicine, Department of Medicine, Baltimore, Maryland, USA.
Background: There are no systematic measures of central line-associated bloodstream infections (CLABSIs) in patients maintaining central venous catheters (CVCs) outside acute care hospitals. To clarify the burden of CLABSIs in these patients, we characterized patients with CLABSI present on hospital admission (POA).
Methods: Retrospective cross-sectional analysis of patients with CLABSI-POA in 3 health systems covering 11 hospitals across Maryland, Washington DC, and Missouri from November 2020 to October 2021.
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