A test for uteroplacental insufficiency based on the idea that a given maternal-foetal unit could be tested by decreasing intervillous space blood flow, offers an individual test for each foetus. Clinically, the use of uterine activity to decrease intervillous space blood flow is the most practical. Following Freeman's suggestion, authors use an endogenous oxytocin test, where the oxytocin discharge is induced by nipple stimulation (EOS).

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