AI Article Synopsis
- Bone metastasis is a major issue in cancer, significantly increasing mortality rates and harming patients' quality of life due to painful complications.
- The interaction between cancer cells and the bone marrow microenvironment plays a key role in treatment resistance and is influenced by cancer-derived exosomes, which help with the spread and colonization of cancer cells in bones.
- This text discusses how understanding exosomes can lead to better insights into bone metastasis and potential clinical applications for treatment.
Article Abstract
Bone is one of the most common sites of cancer metastasis. Once cancer metastasizes to the bone, the mortality rate of cancer patients dramatically increases. Although the exact mechanisms for this observation remain elusive, recent studies have revealed that the complex crosstalk between bone marrow microenvironment and bone metastatic cancer cells is responsible for the induction of treatment resistance. Consequently, bone metastasis is currently considered incurable. Bone metastasis not only impairs the patients' survival, but also negatively affects their quality of life by causing painful complications. It has recently been implicated the regulatory role of exosomes in cancer development and/or progression as a delivery biomaterial between cancer cells and tumor microenvironment. However, little is known as to how exosomes contribute to the progression of bone metastasis by impaction on the crosstalk between bone metastatic cancer cells and bone marrow microenvironment. Here, we highlighted the emerging roles of cancer-derived exosomes in (i) the process of dissemination and bone colonization of bone metastatic cancer cells, (ii) the enhancement of crosstalk between bone marrow microenvironment and bone metastatic cancer cells, (iii) the development of its resultant painful complications, and (iv) the clinical applications of exosomes in the bone metastatic setting.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335387 | PMC |
| http://dx.doi.org/10.1016/j.bonr.2022.101606 | DOI Listing |
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