In chronic experiments on rabbits receiving for 3 months low doses of cholesterol (60 mg per 1 kg of body weight daily), a repeated prolonged (2 h daily) intermittent stimulation of negative and positive emotive zones of the hypothalamus through implanted electrodes (eliciting avoidance and self-stimulation reactions correspondingly),--resulted in uniform disturbances of carbohydrate metabolism. There was a significant reduction of glucose tolerance in comparison with the control group of rabbits with implanted electrodes, as well as a gradual development of a slight, but stable neurogenic hyperglycemia. Simultaneously, in both experimental rabbits groups there were an equal increase of alimentary hypercholesterolemia and a development of persistent neurogenic arterial hypertension.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Climate change has caused heat stress (HS) to become an increasingly severe problem for high-producing dairy herds. Although cooling systems allow milk production to remain nearly constant throughout the year, fertility decreases during summer. Physiological counter-current heat transfer mechanisms maintaining brain/hypothalamic and reproductive functions in cattle are vulnerable to HS.
View Article and Find Full Text PDFDensitometric analysis of GnRH and IBA1 immunocytochemistry in the basal ventromedial hypothalamus of the ewe.
Theriogenology
October 2024
Animal Production Area, Department of Construction and Agronomy, Faculty of Agricultural and Environmental Sciences, University of Salamanca, Avda. Filiberto Villalobos, 119, 37007, Salamanca, Spain. Electronic address:
Gonadotropin releasing hormone (GnRH) synthesis and secretion regulates seasonal fertility. In the brain, the distribution of GnRH-positive neurons is diffuse, hindering efforts to monitor variations in its cellular and tissue levels. Here, we aim at assessing GnRH immunoreactivity in nuclei responsible for seasonal fertility regulation (SFR) within the posterior, anterior, and preoptic areas of the basal hypothalamus during estrous in ewes.
View Article and Find Full Text PDFInhibition of Adult Neurogenesis in Male Mice after Repeated Exposure to Paracetamol Overdose.
Int J Mol Sci
February 2024
Grupo de Neuropsicofarmacología, Instituto IBIMA-Plataforma BIONAND, Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Av. de Carlos Haya, 29010 Málaga, Spain.
Paracetamol, or acetaminophen (N-acetyl-para-aminophenol, APAP), is an analgesic and antipyretic drug that is commonly used worldwide, implicated in numerous intoxications due to overdose, and causes serious liver damage. APAP can cross the blood-brain barrier and affects brain function in numerous ways, including pain signals, temperature regulation, neuroimmune response, and emotional behavior; however, its effect on adult neurogenesis has not been thoroughly investigated. We analyze, in a mouse model of hepatotoxicity, the effect of APAP overdose (750 mg/kg/day) for 3 and 4 consecutive days and after the cessation of APAP administration for 6 and 15 days on cell proliferation and survival in two relevant neurogenic zones: the subgranular zone of the dentate gyrus and the hypothalamus.
View Article and Find Full Text PDFThe dynamic landscape of chromatin accessibility and active regulatory elements in the mediobasal hypothalamus influences the seasonal activation of the reproductive axis in the male quail under long light exposure.
BMC Genomics
February 2024
College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.
Background: In cold and temperate zones, seasonal reproduction plays a crucial role in the survival and reproductive success of species. The photoperiod influences reproductive processes in seasonal breeders through the hypothalamic-pituitary-gonadal (HPG) axis, in which the mediobasal hypothalamus (MBH) serves as the central region responsible for transmitting light information to the endocrine system. However, the cis-regulatory elements and the transcriptional activation mechanisms related to seasonal activation of the reproductive axis in MBH remain largely unclear.
View Article and Find Full Text PDFImmunohistochemical distribution of secretagogin in the mouse brain.
Front Neuroanat
August 2023
Institute for Neuroscience of Castile and Leon (INCyL), Universidad de Salamanca, Salamanca, Spain.
Introduction: Calcium is essential for the correct functioning of the central nervous system, and calcium-binding proteins help to finely regulate its concentration. Whereas some calcium-binding proteins such as calmodulin are ubiquitous and are present in many cell types, others such as calbindin, calretinin, and parvalbumin are expressed in specific neuronal populations. Secretagogin belongs to this latter group and its distribution throughout the brain is only partially known.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!